Innate immunity: an overview

被引：866
作者：
Beutler, B [1 ]
机构：
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
来源：
MOLECULAR IMMUNOLOGY | 2004年 / 40卷 / 12期
关键词：
innate immunity; lipopolysaccharide; sepsis; toll like receptors; TIR adapter proteins; infection;
D O I：
10.1016/j.molimm.2003.10.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Though sometimes portrayed as "new," the science of innate immunity made its start more than 100 years ago. Recent progress has reflected the application of new methods to old problems. In particular, genetic dissection of innate immune pathways has been pursued with great success in model organisms. This has opened the way to an understanding of innate immune sensing. The effector arm of innate immunity has also been tackled, largely though the use of biochemical methods. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：845 / 859
页数：15
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