Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

被引:17
作者
Trejo-Soto, Claudia [1 ]
Hernandez-Machado, Aurora [2 ,3 ,4 ]
机构
[1] Pontificia Univ Catolica Valparaiso, Inst Fis, Casilla 4059, Chile
[2] Univ Barcelona, Dept Fis Mat Condensada, Av Diagonal 645, Barcelona 08028, Spain
[3] Ctr Recerca Matemat, Edifici C,Campus Bellaterra, Bellaterra 08193, Spain
[4] Univ Barcelona, Inst Nanosci & Nanotechnol IN2UB, Av Diagonal 645, Barcelona 08028, Spain
关键词
blood; viscosity; microfluidics; hematocrit; shear rate; CELL; RHEOLOGY; FLOW; AGGREGATION; MECHANICS; MICROFLUIDICS; DEFORMABILITY; TEMPERATURE; SUSPENSIONS; DEPENDENCE;
D O I
10.3390/mi13030357
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The rheological properties of blood depend highly on the properties of its red blood cells: concentration, membrane elasticity, and aggregation. These properties affect the viscosity of blood as well as its shear thinning behavior. Using an experimental analysis of the interface advancement of blood in a microchannel, we determine the viscosity of different samples of blood. In this work, we present two methods that successfully normalize the viscosity of blood for a single and for different donors, first according to the concentration of erythrocytes and second according to the shear rate. The proposed methodology is able to predict the health conditions of the blood samples by introducing a non-dimensional coefficient that accounts for the response to shear rate of the different donors blood samples. By means of these normalization methods, we were able to determine the differences between the red blood cells of the samples and define a range where healthy blood samples can be described by a single behavior.
引用
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页数:20
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