Immune-modulating and anti-inflammatory marine compounds against cancer

被引：37
作者：
Florean, Cristina [1 ]
Dicato, Mario [1 ]
Diederich, Marc [2 ]
机构：
[1] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg
[2] Seoul Natl Univ, Coll Pharm, 1 Gwanak Ro, Seoul 08826, South Korea
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 80卷
基金：
新加坡国家研究基金会;
关键词：
Marine compounds; Anticancer treatment; Chronic inflammation; Immune system; Immunotherapy of cancer; NF-KAPPA-B; NATURAL-PRODUCTS; PHASE-I; POLYSACCHARIDE ASCOPHYLLAN; COLORECTAL-CANCER; DENDRITIC CELLS; FATTY-ACIDS; NKT CELLS; FUCOIDAN; INFLAMMATION;
D O I：
10.1016/j.semcancer.2020.02.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at reverting pro-tumor inflammation and stimulating the antitumor immune components are being actively searched, and the anticancer effects of many candidate drugs have been linked to their ability to modulate the immune system. Marine organisms constitute a rich reservoir of new bioactive molecules; some of them have already been exploited for pharmaceutical use, whereas many others are undergoing clinical or preclinical investigations for the treatment of different diseases, including cancer. In this review, we will discuss the immune-modulatory properties of marine compounds for their potential use in cancer prevention and treatment and as possible tools in the context of cancer immunotherapy.
引用
收藏
页码：58 / 72
页数：15
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