The Role of Fructose as a Cardiovascular Risk Factor: An Update

被引:34
作者
Busnatu, Stefan-Sebastian [1 ]
Salmen, Teodor [2 ]
Pana, Maria-Alexandra [1 ]
Rizzo, Manfredi [3 ]
Stallone, Tiziana [4 ]
Papanas, Nikolaos [5 ]
Popovic, Djordje [6 ]
Tanasescu, Denisa [7 ]
Serban, Dragos [8 ,9 ]
Stoian, Anca Pantea [10 ]
机构
[1] Carol Davila Univ Med & Pharm, Cardiol Dept Bucharest, Bucharest 050474, Romania
[2] Prof Dr NC Paulescu Natl Inst Diabet Nutr & Metab, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania
[3] Univ Palermo, Sch Med, Dept Hlth Promot Sci Maternal & Infantile Care, Internal Med & Med Specialties PROMISE, I-90100 Palermo, Italy
[4] Italian Council & Pens Funds Biologist Enpab, I-00153 Rome, Italy
[5] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Diabet Ctr, Diabet Foot Clin,Dept Internal Med 2, Alexandroupolis 68100, Greece
[6] Univ Novi Sad, Med Fac, Novi Sad 21102, Serbia
[7] Lucian Blaga Univ, Fac Med, Dept Dent Med & Nursing 4, Sibiu 550024, Romania
[8] Carol Davila Univ Med, Dept Gen Surg, Bucharest 020021, Romania
[9] Emergency Univ Hosp Bucharest, Forth Dept Gen Surg, Bucharest 050098, Romania
[10] Carol Davila Univ Med, Dept Diabet Nutr & Metab Dis, Bucharest 050474, Romania
关键词
fructose; cardiovascular disease; nutrition; risk factors; lipoproteins; LOW-DENSITY-LIPOPROTEIN; DIETARY FRUCTOSE; INSULIN-RESISTANCE; PARTICLE-SIZE; CONSUMPTION;
D O I
10.3390/metabo12010067
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is increasing presence of fructose in food and drinks, and some evidence suggests that its higher consumption increases cardiovascular risk, although the mechanisms still remain not fully elucidated. Cardiovascular diseases (CVD) are still responsible for one-third of deaths worldwide, and therefore, their prevention should be assessed and managed comprehensively and not by the evaluation of individual risk factor components. Lifestyle risk factors for CVD include low degree of physical activity, high body mass index, alcohol consumption, smoking, and nutritional factors. Indeed, nutritional risk factors for CVD include unhealthy dietary behaviors, such as high intake of refined foods, unhealthy fats, added sugars, and sodium and a low intake of fruits, vegetables, whole grains, fiber, fish, and nuts. Even though there is no definitive association between CVD incidence and high consumption of total sugar, such as sucrose and fructose, there is, however, evidence that total sugars, added sugars, and fructose are harmfully associated with CVD mortality. Since high fructose intake is associated with elevated plasma triglyceride levels, as well as insulin resistance, diabetes hyperuricemia, and non-alcoholic fatty liver disease, further longitudinal studies should be conducted to fully elucidate the potential association between certain sugars and CVD.
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页数:8
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