hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis

被引:5
作者
Zhou, Yong [1 ,2 ]
Tong, Zhongkai [1 ,2 ]
Zhu, Xiaoxiao [1 ,2 ]
Huang, Shaoqing [1 ,2 ]
Dong, Zhaoxing [1 ,2 ]
Ye, Zhenyue [1 ,2 ]
机构
[1] Univ Chinese Acad Sci, HwaMei Hosp, Resp Dept, Ningbo, Peoples R China
[2] Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo, Peoples R China
来源
FRONTIERS IN SURGERY | 2022年 / 9卷
关键词
hsa_circ_0072309; NSCLC; diagnosis; prognosis; GEO; CANCER; INVASION;
D O I
10.3389/fsurg.2022.842292
中图分类号
R61 [外科手术学];
学科分类号
摘要
Circular RNAs (circRNAs), which fall into the category of endogenous ncRNAs, are linked to disease progression of neoplastic diseases. Whereas, it remains uncharacterized regarding hsa_circ_0072309's function and implications in lung carcinoma (LC). Gene Expression Omnibus (GEO) database was utilized for identifying circRNAs with aberrantly expression in LC. qRT-PCR was responsible for determining hsa_circ_0072309 levels in lung adenocarcinoma (LAC). Also, its involvement in LC cell progression was investigated. Experimentally, hsa_circ_0072309 was identified as one of the most aberrantly down-regulated circRNAs in the GEO database (GSE101684 and GSE112214). qRT-PCR revealed notably down-regulated hsa_circ_0072309 in LAC tissue, which had a close association with adverse 3-year survival, as well as LNM and advanced TNM stage. Based on ROC, the AUC of hsa_circ_0072309 was determined to be 0.887, and its specificity and susceptibility can be improved by combined detection of either CYFRA21-1 or CEA. In a word, hsa_circ_0072309 is lowly expressed in lung cancer patients and the survival rate of lowly expressed patients is significantly lower, a candidate marker with prognostic utility for the disease.
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页数:8
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