One-pot synthesis of fluorinated 2-arylchroman-4-one derivatives from 2-(triisopropylsilyl)ethynylphenols and aromatic aldehydes

被引：4

作者：

Politanskaya, Larisa ^{[1
]}

Wang, Jiaying ^{[1
,2
]}

Troshkova, Nadezhda ^{[1
]}

Chuikov, Igor ^{[1
]}

Bagryanskaya, Irina ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Ac Lavrentiev Ave 9, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Pirogova St 2, Novosibirsk 630090, Russia

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2022年 / 263卷

关键词：

fluorinated flavanones; TIPS-ethynylphenols; p-toluenesulfonic acid; hydration reaction; cycloaddition; NMR analysis; CATALYZED ASYMMETRIC HYDROGENATION; HIGHLY ENANTIOSELECTIVE PATHWAY; OXA-MICHAEL ADDITION; BIOLOGICAL EVALUATION; IONIC LIQUID; ANTIPROLIFERATIVE ACTIVITY; CYTOTOXICITY EVALUATION; MEDIATED APOPTOSIS; ARYLBORONIC ACIDS; FACILE SYNTHESIS;

D O I：

10.1016/j.jfluchem.2022.110045

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A facile p-toluenesulfonic acid-catalyzed one-pot synthesis of biologically interesting fluorinated 2-arylchroman-4-one derivatives from 2-(triisopropylsilyl)ethynylphenols and aromatic aldehydes is described. This synthetic method is metal-free, operationally simple, cheap and productive. It provides a rapid access to the title compounds as well as their 3-benzylidene and 8-cinnamoyl derivatives, that are of interest as objects for the evaluation of their pharmacological properties.

引用

页数：15

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