Biomarkers in Severe Asthma

被引：46

作者：

Wan, Xiao Chloe

Woodruff, Prescott G. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Sleep & Allergy, 513 Parnassus Ave,HSE 1305, San Francisco, CA 94143 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 03期

关键词：

Severe asthma; Biomarker; Eosinophil; Periostin; Exhaled nitric oxide; Endotype; SPUTUM EOSINOPHIL COUNTS; EXHALED NITRIC-OXIDE; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; SERUM PERIOSTIN; AIRWAY INFLAMMATION; CLUSTER-ANALYSIS; CELL COUNTS; EXACERBATIONS; MEPOLIZUMAB;

D O I：

10.1016/j.iac.2016.03.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non-type 2 inflammatory mechanisms in asthma will soon be the major obstacle to the development of new treatments and management strategies in severe asthma. Biomarkers can play a role in these investigations as well by providing insight into the underlying biology in human studies of patients with severe asthma.

引用

页码：547 / +

页数：12

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