Biomarkers in Severe Asthma

被引：46

作者：

Wan, Xiao Chloe

Woodruff, Prescott G. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Sleep & Allergy, 513 Parnassus Ave,HSE 1305, San Francisco, CA 94143 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 03期

关键词：

Severe asthma; Biomarker; Eosinophil; Periostin; Exhaled nitric oxide; Endotype; SPUTUM EOSINOPHIL COUNTS; EXHALED NITRIC-OXIDE; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; SERUM PERIOSTIN; AIRWAY INFLAMMATION; CLUSTER-ANALYSIS; CELL COUNTS; EXACERBATIONS; MEPOLIZUMAB;

D O I：

10.1016/j.iac.2016.03.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non-type 2 inflammatory mechanisms in asthma will soon be the major obstacle to the development of new treatments and management strategies in severe asthma. Biomarkers can play a role in these investigations as well by providing insight into the underlying biology in human studies of patients with severe asthma.

引用

页码：547 / +

页数：12

共 87 条

[1] ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 [J].

American Thoracic Society ;

European Respiratory Society .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (08) :912-930

[2] New and future strategies to improve asthma control in children [J].

Anderson, William C., III ;

Szefler, Stanley J. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 136 (04) :848-859

[3] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[4] Adiponectin in Asthma and Obesity: Protective Agent or Risk Factor for More Severe Disease? [J].

Azambuja, Renato de Lima ;

da Costa Santos Azambuja, Layla Salomao Eulalio ;

Costa, Claudia ;

Rufino, Rogerio .

LUNG, 2015, 193 (05) :749-755

[5] Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial [J].

Baeten, Dominique ;

Baraliakos, Xenofon ;

Braun, Juergen ;

Sieper, Joachim ;

Emery, Paul ;

van der Heijde, Desiree ;

McInnes, Iain ;

van Laar, Jacob M. ;

Landewe, Robert ;

Wordsworth, Paul ;

Wollenhaupt, Juergen ;

Kellner, Herbert ;

Paramarta, Jacqueline ;

Wei, Jiawei ;

Brachat, Arndt ;

Bek, Stephan ;

Laurent, Didier ;

Li, Yali ;

Wang, Ying A. ;

Bertolino, Arthur P. ;

Gsteiger, Sandro ;

Wright, Andrew M. ;

Hueber, Wolfgang .

LANCET, 2013, 382 (9906) :1705-1713

[6] Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma [J].

Bel, Elisabeth H. ;

Wenzel, Sally E. ;

Thompson, Philip J. ;

Prazma, Charlene M. ;

Keene, Oliver N. ;

Yancey, Steven W. ;

Ortega, Hector G. ;

Pavord, Ian D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (13) :1189-1197

[7] Induced sputum cell counts in healthy adults [J].

Belda, J ;

Leigh, R ;

Parameswaran, K ;

O'Byrne, PM ;

Sears, MR ;

Hargreave, FE .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (02) :475-478

[8] Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses [J].

Blanchard, C. ;

Mingler, M. K. ;

McBride, M. ;

Putnam, P. E. ;

Collins, M. H. ;

Chang, G. ;

Stringer, K. ;

Abonia, J. P. ;

Molkentin, J. D. ;

Rothenberg, M. E. .

MUCOSAL IMMUNOLOGY, 2008, 1 (04) :289-296

[9] Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines [J].

Bossley, Cara J. ;

Fleming, Louise ;

Gupta, Atul ;

Regamey, Nicolas ;

Frith, Jennifer ;

Oates, Timothy ;

Tsartsali, Lemonia ;

Lloyd, Clare M. ;

Bush, Andrew ;

Saglani, Sejal .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (04) :974-U469

[10] Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial [J].

Brightling, Christopher E. ;

Chanez, Pascal ;

Leigh, Richard ;

O'Byrne, Paul M. ;

Korn, Stephanie ;

She, Dewei ;

May, Richard D. ;

Streicher, Katie ;

Ranade, Koustubh ;

Piper, Edward .

LANCET RESPIRATORY MEDICINE, 2015, 3 (09) :692-701

← 1 2 3 4 5 6 7 8 9 →