Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis

被引:3
作者
de Castro Ribeiro, M [1 ]
Barbosa-Coutinho, L [1 ]
Mugnol, F [1 ]
Hilbig, A [1 ]
Palmini, A [1 ]
da Costa, JC [1 ]
Neto, EP [1 ]
Paglioli, E [1 ]
机构
[1] PUC, Hosp Sao Lucas, Porto Alegre Epilepsy Surg Program, Porto Alegre, RS, Brazil
关键词
hippocampal sclerosis; corpora amylacea; temporal lobe epilepsy;
D O I
10.1590/S0004-282X2003000600010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hippocampal sclerosis (HS) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. Beside, there are an increased density of corpora amylacea (CA) founded in 6 to 63% of those cases. Objective: verify the presence of CA and the clinical correlates of their occurrence in a consective series of patients undergoing temporal surgery with diagnosis of HS. Method: We reviewed 72 hippocampus specimens from January 1997 to July 2000. Student's t test for independent, samples, ANOVA and Tukey test were performed for statistical analysis. Results: CA were found in 35 patients (49%), whose mean epilepsy duration (28.7 years) was significantly longer than that group of patients without CA (19.5 years, p= 0.001). Besides, when CA were found, duration was also significantly correlated with distribution within hippocampus: 28.7 years with diffuse distribution of CA, 15.4 with exclusively subpial and 17.4 years with distribution subpial plus perivascular (p= 0.001). Conclusion: Our findings corroborate the presence of CA in patients with HS and suggest that a longer duration of epilepsy correlate with a more distribution of CA in hippocampus.
引用
收藏
页码:942 / 945
页数:4
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