Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation

被引:27
作者
Arighi, Andrea [1 ]
Arcaro, Marina [1 ]
Fumagalli, Giorgio Giulio [1 ]
Carandini, Tiziana [1 ]
Pietroboni, Anna Margherita [1 ]
Sacchi, Luca [1 ,2 ]
Fenoglio, Chiara [2 ]
Serpente, Maria [1 ]
Sorrentino, Federica [2 ]
Isgro, Giovanni [1 ]
Turkheimer, Federico [3 ]
Scarpini, Elio [1 ,2 ]
Galimberti, Daniela [1 ,2 ]
机构
[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurodegenerat Dis Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
[2] Univ Milan, Milan, Italy
[3] Kings Coll London, Dept Neuroimaging, Inst Psychiat Psychol & Neurosci, London, England
关键词
Glymphatic system; Aquaporin; 4; Amyloid-beta; Cerebrospinal fluid; Alzheimer's disease; Frontotemporal dementia; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; DIAGNOSTIC-CRITERIA; PREVALENCE; PATHOLOGY;
D O I
10.1186/s13195-022-01077-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). In this study, cerebrospinal fluid (CSF) concentration of AQP4, amyloid-beta, total tau and P-tau were determined in 103 CSF samples from patients affected by neurodegenerative dementias (AD and FTD) or psychiatric diseases and 21 controls. Significantly higher levels of AQP4 were found in AD and FTD patients compared to subjects not affected by neurodegenerative diseases, and a significant, positive correlation between AQP4 and total tau levels was found. This evidence may pave the way for future studies focused on the role of this channel protein in the clinical assessment of the glymphatic function and degree of neurodegeneration.
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页数:10
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