Water-soluble PEGylated silicon nanoparticles and their assembly into swellable nanoparticle aggregates

被引：9

作者：

Xu, Zejing ^{[1
]}

Li, Yejia ^{[1
]}

Zhang, Boyu ^{[1
]}

Purkait, Tapas ^{[1
]}

Alb, Alina ^{[2
]}

Mitchell, Brian S. ^{[3
]}

Grayson, Scott M. ^{[1
]}

Fink, Mark J. ^{[1
]}

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

[2] Tulane Univ, Dept Phys & Engn Phys, New Orleans, LA 70118 USA

[3] Tulane Univ, Dept Chem & Biomol Engn, New Orleans, LA 70118 USA

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2015年 / 17卷 / 01期

基金：

美国国家科学基金会;

关键词：

Silicon; Nanoparticles; PEG; Nanohydrogel; Nanocolloids; QUANTUM DOTS; POROUS SILICON; MECHANOCHEMICAL SYNTHESIS; FUNCTIONALIZED SILICON; CLICK CHEMISTRY; DRUG-DELIVERY; SURFACE; SI; NANOCRYSTALS; FLUORESCENT;

D O I：

10.1007/s11051-015-2869-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble silicon nanoparticles were synthesized by grafting PEG polymers onto functionalized silicon nanoparticles with distal alkyne or azide moieties. The surface-functionalized silicon nanoparticles were produced in one step from the reactive high-energy ball milling (RHEBM) of silicon wafers with a mixture of either 5-chloro-1-pentyne in 1-pentyne or 1,7 octadiyne in 1-hexyne to afford air and water-stable chloroalkyl or alkynyl-terminated nanoparticles, respectively. Nanoparticles with the xchloroalkyl substituents were easily converted to xazidoalkyl groups through the reaction of the Si nanoparticles with sodium azide in DMF. The azido-terminated nanoparticles were then grafted with mono-alkynyl-PEG polymers using a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction to afford core-shell silicon nanoparticles with a covalently attached PEG shell. Covalently linked Si nanoparticle clusters were synthesized via the CuAAC "click'' reaction of functional Si NPs with alpha,omega-functional PEG polymers of various lengths. Dynamic light scattering studies show that the flexible globular nanoparticle aggregates undergo a solvent-dependent change in volume (ethanol>dichloromethane>toluene) similar in behavior to hydrogel nanocomposites.

引用

页数：16

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