In vitro activity of antifungal drugs against Plasmodium falciparum field isolates

被引：0
作者：
Pongratz, Peter [1 ,2 ,3 ,4 ]
Kurth, Florian [1 ,2 ,3 ,5 ]
Ngoma, Ghyslain Mombo [1 ,2 ,3 ,6 ]
Basra, Arti [1 ,2 ,3 ]
Ramharter, Michael [1 ,2 ,3 ]
机构：
[1] Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria
[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
[3] Univ Tubingen, Inst Trop Med, Tubingen, Germany
[4] Kaiser Franz Josef Hosp, Dept Med Infect Dis & Trop Med 4, Vienna, Austria
[5] Univ Hosp Carl Gustav Carus, Dept Neonatol & Paediat Intens Care, Dresden, Germany
[6] Univ Sci Sante, Dept Parasitol Mycol, Fac Med, Libreville, Gabon
来源：
WIENER KLINISCHE WOCHENSCHRIFT | 2011年 / 123卷
关键词：
Antifungal; drug sensitivity; histidine-rich protein 2; malaria; Plasmodium falciparum; Gabon; Africa; RANDOMIZED CONTROLLED-TRIAL; AMPHOTERICIN-B; MALARIA; KETOCONAZOLE; GABON; ARTESUNATE; CLOTRIMAZOLE; 5-FLUOROCYTOSINE; PHARMACOKINETICS; ANTIMALARIALS;
D O I：
10.1007/s00508-011-0021-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The increasing resistance of the malaria parasite Plasmodium falciparum to currently available drugs necessitates a continuous effort to develop new antimalarial agents. We therefore aimed to assess the in vitro activity of the antifungal drugs clotrimazole, fluconazole, ketoconazole, itraconazole, voriconazole, flucytosine, amphotericin B, and caspofungin against field isolates of P. falciparum from Lambarene, Gabon. Using the histidin-rich protein 2 (HRP-2) assay we determined the drug susceptibility (EC50, EC90) of 16 field isolates obtained from outpatients attending the Albert Schweitzer Hospital in Lambarene, Gabon. For fluconazole, itraconazole and caspofungin the in vitro growth inhibition of these drugs is reported for the first time. Our data indicate that clotrimazole, fluconazole, itraconazole and caspofungin show median EC50 values of 3.1 mu g/mL, 1.9 mu g/mL, 1.1 mu g/mL and 1.1 mu g/mL respectively. Ketoconazole, voriconazole, flucytosine and amphotercin B showed no relevant growth inhibition within the range of drug concentrations used in this study.
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页码：26 / 30
页数：5
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