Renal Liver-Type Fatty Acid Binding Protein Attenuates Angiotensin II-Induced Renal Injury

被引：26

作者：

Ichikawa, Daisuke

Kamijo-Ikemori, Atsuko ^{[2
]}

Sugaya, Takeshi

Yasuda, Takashi

Hoshino, Seiko ^{[2
]}

Igarashi-Migitaka, Jyunko ^{[2
]}

Hirata, Kazuaki ^{[2
]}

Kimura, Kenjiro ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Div Nephrol & Hypertens, Dept Internal Med,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

[2] St Marianna Univ, Sch Med, Dept Anat, Kawasaki, Kanagawa 2168511, Japan

来源：

HYPERTENSION | 2012年 / 60卷 / 04期

基金：

日本学术振兴会;

关键词：

angiotensin II; L-type fatty acid binding protein; oxidative stress; hypertension; tubulointerstitial damage; TRANSGENIC MICE; TUBULOINTERSTITIAL DAMAGE; URINARY-EXCRETION; L-FABP; KIDNEY; REFLECTS; RAT;

D O I：

10.1161/HYPERTENSIONAHA.112.199828

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang II and WT-Ang II) for 28 days. Control mice were injected with saline only (Tg-control and WT-control). hL-FABP was expressed in proximal tubules of Tg mice. After a high-dose injection of Ang II, renal gene and protein expressions of hL-FABP in Tg-Ang II mice increased significantly compared with Tg-control mice. Urinary excretion of L-FABP was significantly greater in Tg-Ang II than in Tg-control mice. Blood pressure levels in both groups increased to a similar extent. Upregulation of monocyte chemoattractant protein 1 expression, macrophage infiltration in the interstitium, tubulointerstitial damage, and depositions of type I and III collagens were observed in both Tg-Ang II and WT-Ang II mice. However, these effects were less pronounced in Tg-Ang II compared with WT-Ang II mice. The level of renal N-(hexanoyl) lysine, an oxidative stress marker, was significantly higher in WT-Ang II than in Tg-Ang II mice. In conclusion, renal hL-FABP reduced oxidative stress in Ang II-induced renal injury and attenuated tubulointerstitial damage. (Hypertension. 2012; 60: 973-980.). Online Data Supplement

引用

页码：973 / +

页数：14

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