Methylselenocysteine Treatment Leads to Diselenide Formation in Human Cancer Cells: Evidence from X-ray Absorption Spectroscopy Studies

被引：20

作者：

Weekley, Claire M. ^{[1
,2
]}

Aitken, Jade B. ^{[1
,2
]}

Musgrave, Ian F. ^{[3
]}

Harris, Hugh H. ^{[1
,2
]}

机构：

[1] Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia

[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[3] Univ Adelaide, Sch Med Sci, Adelaide, SA 5005, Australia

来源：

BIOCHEMISTRY | 2012年 / 51卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

PREVENTION TRIAL SELECT; VITAMIN-E; SELENIUM SUPPLEMENTATION; METHYLSELENINIC ACID; PROSTATE-CANCER; IN-VITRO; CHEMOPREVENTION;

D O I：

10.1021/bi201462u

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in human neuroblastoma cells. Cells treated with MeSeCys contain a significant diselenide component, which is absent from SeMet-treated cells and suggests that metabolites of MeSeCys are capable of altering the redox status of the cells. The differences in the speciation of Se in the selenoamino acid-treated cells may provide insight into the differing anticancer activities of MeSeCys and SeMet.

引用

页码：736 / 738

页数：3

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