Urine analysis of patients exposed to phenylarsenic compounds via accidental pollution

被引：24

作者：

Kinoshita, Kenji ^{[1
]}

Noguchi, Ayano ^{[1
]}

Ishii, Kazuhiro ^{[2
]}

Tamaoka, Akira ^{[2
]}

Ochi, Takafumi ^{[3
]}

Kaise, Toshikazu ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Lab Environm Chemodynam, Tokyo 1920392, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan

[3] Teikyo Univ, Fac Pharmaceut Sci, Toxicol Lab, Kanagawa 1990195, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 867卷 / 02期

关键词：

chemical warfare agents; LC-ICP-MS; urine analysis;

D O I：

10.1016/j.jchromb.2008.03.033

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

New methods involving high-performance liquid chromatography/inductively coupled plasma mass spectrometry were examined for the determination of phenylarsenic compounds derived from chemical warfare agents. Several methods were examined for the separation of diphenylarsinic acid (DPAA), phenylarsonic acid, phenylmethylarsinic acid (PMAA), phenyldimethylarsine oxide, and diphenylmethylarsine oxide. Analysis of the urine samples of the patients exposed to phenylarsenic compounds indicated that the main phenylarsenic components were DPAA and PMAA; moreover, some unknown arsenicals, which were also found in contaminated groundwater and rice samples, were also detected. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：179 / 188

页数：10

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