Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus

被引:29
作者
Helminen, Olli [1 ,2 ]
Pokka, Tytti [1 ,2 ]
Tossavainen, Paivi [1 ,2 ]
Ilonen, Jorma [3 ,4 ]
Knip, Mikael [5 ,6 ,7 ,8 ,9 ]
Veijola, Riitta [1 ,2 ]
机构
[1] Oulu Univ Hosp, Med Res Ctr, PEDEGO Res Unit, Dept Pediat, Oulu, Finland
[2] Univ Oulu, Oulu, Finland
[3] Univ Turku, Immunogenet Lab, Turku, Finland
[4] Turku Univ Hosp, Turku, Finland
[5] Tampere Univ Hosp, Tampere Ctr Child Hlth Res, Tampere, Finland
[6] Univ Helsinki, Childrens Hosp, Helsinki, Finland
[7] Helsinki Univ Hosp, Helsinki, Finland
[8] Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland
[9] Folkhalsan Res Ctr, Helsinki, Finland
基金
芬兰科学院;
关键词
Type 1 diabetes mellitus; Autoantibodies; Glucose intolerance; Self-monitoring; Blood-glucose; Prediabetes;
D O I
10.1016/j.diabres.2016.07.027
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: Continuous glucose monitoring (CGM) parameters, self-monitored blood glucose (SMBG), HbA1c and oral glucose tolerance test (OGTT) were studied during preclinical type 1 diabetes mellitus. Methods: Ten asymptomatic children with multiple (>= 2) islet autoantibodies (cases) and 10 age and sex-matched autoantibody-negative controls from the Type 1 Diabetes Prediction and Prevention (DIPP) Study were invited to 7-day CGM with Dexcom G4 Platinum Sensor. HbA1c and two daily SMBG values (morning and evening) were analyzed. Five-point OGTTs were performed and carbohydrate intake was assessed by food records. The matched pairs were compared with the paired sample t-test. Results: The cases showed higher mean values and higher variation in glucose levels during CGM compared to the controls. The time spent >= 7.8 mmol/l was 5.8% in the cases compared to 0.4% in the controls (p = 0.040). Postprandial CGM values were similar except after the dinner (6.6 mmol/l in cases vs. 6.1 mmol/l in controls; p = 0.023). When analyzing the SMBG values higher mean level, higher evening levels, as well as higher variation were observed in the cases when compared to the controls. HbA1c was significantly higher in the cases [5.7% (39 mmol/mol) vs. 5.3% (34 mmol/mol); p = 0.045]. No differences were observed in glucose or C-peptide levels during OGTT. Daily carbohydrate intake was slightly higher in the cases (254.2 g vs. 217.7 g; p = 0.034). Conclusions: Glucose levels measured by CGM and SMBG are useful indicators of dysglycemia during preclinical type 1 diabetes mellitus. Increased evening glucose values seem to be common in children with preclinical type 1 diabetes mellitus. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:89 / 96
页数:8
相关论文
共 50 条
  • [41] Risk Factors of Hypoglycemia in Patients with Type 2 Diabetes Mellitus: A Study Based on Continuous Glucose Monitoring
    Torimoto, Keiichi
    Okada, Yosuke
    Hajime, Maiko
    Tanaka, Kenichi
    Tanaka, Yoshiya
    DIABETES TECHNOLOGY & THERAPEUTICS, 2018, 20 (09) : 603 - 612
  • [42] Association between scanning frequency of flash glucose monitoring and continuous glucose monitoring-derived glycemic makers in children and adolescents with type 1 diabetes
    Suzuki, Junichi
    Urakami, Tatsuhiko
    Yoshida, Kei
    Kuwabara, Remi
    Mine, Yusuke
    Aoki, Masako
    Morioka, Ichiro
    PEDIATRICS INTERNATIONAL, 2021, 63 (02) : 154 - 159
  • [43] Diagnostic performance of glycated haemoglobin (HbA1c) for diabetes mellitus in dogs
    Oikonomidis, I. L.
    Tsouloufi, T. K.
    Tzenetidou, Z.
    Ceron, J. J.
    Tvarijonaviciute, A.
    Konstantinidis, A. O.
    Soubasis, N.
    VETERINARY JOURNAL, 2023, 294
  • [44] Impact of demographics and disease progression on the relationship between glucose and HbA1c
    Claussen, Anetta
    Moller, Jonas B.
    Kristensen, Niels R.
    Klim, Soren
    Kjellsson, Maria C.
    Ingwersen, Steen H.
    Karlsson, Mats O.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 104 : 417 - 423
  • [45] Effect of Total Hemoglobin level on HbA1c value in Type 2 Diabetes Mellitus patients
    Narayanan, Sreedev
    Dash, Prakruti
    Mahajan, Preetam
    BANGLADESH JOURNAL OF MEDICAL SCIENCE, 2020, 19 (01): : 110 - 113
  • [46] Dysregulation of glucose metabolism in preclinical type 1 diabetes
    Veijola, Riitta
    Koskinen, Maarit
    Helminen, Olli
    Hekkala, Anne
    PEDIATRIC DIABETES, 2016, 17 : 25 - 30
  • [47] Accuracy of a portable glucose meter and of a Continuous Glucose Monitoring device used at home by patients with type 1 diabetes
    Francescato, M. P.
    Geat, M.
    Stel, G.
    Cauci, S.
    CLINICA CHIMICA ACTA, 2012, 413 (1-2) : 312 - 318
  • [48] Accuracy of Continuous Glucose Monitoring in Pregnancy During Inpatient Acute Glycemic Variability in Women with Type 1 Diabetes Mellitus
    Croker, Emma E.
    Rowe, Christopher W.
    Mohammad, Naeel
    Wynne, Katie
    JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 2023, 17 (01): : 253 - 255
  • [49] The metabolic deterioration that antedates diabetes: personal trajectories of HbA1c and fasting glucose as early indicators and possible triggers for intervention
    Dankner, Rachel
    Bergman, Michael
    Danoff, Ann
    Qureshi, Sana
    Whitford, Ian
    Kaviani, Nargess
    Dynkevich, Yevgeniya
    Roth, Jesse
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2013, 29 (01) : 1 - 7
  • [50] Pitfalls of HbA1c in the Diagnosis of Diabetes
    Bergman, Michael
    Abdul-Ghani, Muhammad
    Neves, Joao Sergio
    Monteiro, Mariana P.
    Medina, Jose Luiz
    Dorcely, Brenda
    Buysschaert, Martin
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (08) : 2803 - 2811