Efficient Synthesis of Dihydropyrimidines Using a Highly Ordered Mesoporous Functionalized Pyridinium Organosilica

被引：8
作者：
Rajabi, Fatemeh [1 ]
Sillanpaa, Mika [2 ,3 ]
Len, Christophe [4 ]
Luque, Rafael [5 ]
机构：
[1] Payame Noor Univ, Dept Sci, POB 19395-4697, Tehran 19569, Iran
[2] Aarhus Univ, Dept Biol & Chem Engn, DK-8000 Aarhus, Denmark
[3] Shoolini Univ, Int Res Ctr Nanotechnol Himalayan Sustainabil IRC, Solan 173212, India
[4] PSL Res Univ, Inst Chem Life & Hlth Sci, Chim Paris Tech, CNRS, 11 Rue Pierre & Marie Curie, F-75005 Paris, France
[5] Univ Cordoba, Dept Quim Organ, Campus Rabanales,Edificio Marie Curie C-3, E-14014 Cordoba, Spain
来源：
CATALYSTS | 2022年 / 12卷 / 03期
关键词：
biginelli reaction; dihydropyrimidines; pyridinium-functionalized organosilica; reusable nanocatalyst; ONE-POT SYNTHESIS; BIGINELLI REACTION; CONDENSATION REACTION; ASSISTED SYNTHESIS; REUSABLE CATALYST; ROOM-TEMPERATURE; ORGANIC GROUPS; ACID; CHLORIDE; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES;
D O I：
10.3390/catal12030350
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A Bronsted acidic ionic solid pyridinium-functionalized organosilica network (PMO-Py-IL) was demonstrated to efficiently catalyse one-pot Biginelli condensation reaction. The green synthesis of 3,4-dihydro-2(H)-pyrimidinones (DHPMs) with high yield was carried out via one-pot three component condensation of beta- dicarbonyls, aldehydes, and urea in the presence of a catalytic amount of PMO-Py-IL nanomaterial as an efficient nanocatalyst under solvent free conditions. Furthermore, the catalyst showed outstanding stability and could be easily separated and reused for at least ten reaction runs without significant loss of activity and product selectivity. The green protocol features simple set-up, cost-effectiveness, easy work-up, eco-friendly and mild reaction conditions.
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页数：10
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