Chloroquine Inhibits Stemness of Esophageal Squamous Cell Carcinoma Cells Through Targeting CXCR4-STAT3 Pathway

被引：13

作者：

Yue, Dongli ^{[1
,2
]}

Zhang, Daiqun ^{[1
]}

Shi, Xiaojuan ^{[1
]}

Liu, Shasha ^{[1
]}

Li, Anqi ^{[1
]}

Wang, Dong ^{[1
,2
]}

Qin, Guohui ^{[1
,2
]}

Ping, Yu ^{[1
]}

Qiao, Yamin ^{[1
,2
]}

Chen, Xinfeng ^{[1
,2
]}

Wang, Feng ^{[2
]}

Chen, Renyin ^{[3
]}

Zhao, Song ^{[4
]}

Wang, Lidong ^{[5
,6
]}

Zhang, Yi ^{[1
,7
,8
]}

机构：

[1] Zhengzhou Univ, Biotherapy Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Canc Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China

[3] Zhengzhou Univ, Dept Pathol, Affiliated Hosp 1, Zhengzhou, Peoples R China

[4] Zhengzhou Univ, Dept Thorac Surg, Affiliated Hosp 1, Zhengzhou, Peoples R China

[5] Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou, Peoples R China

[6] Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Fhavent 8 Treatment, Zhengzhou, Peoples R China

[7] Zhengzhou Univ, Sch Life Sci, Zhengzhou, Peoples R China

[8] Henan Key Lab Tumor Immunol & Biotherapy, Zhengzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

基金：

中国国家自然科学基金;

关键词：

esophageal squamous cell carcinoma (ESCC); cancer stem cells (CSCs); CXCR4; chloroquine (CQ); STAT3; CANCER STATISTICS; CXCR4; METASTASIS; EXPRESSION; MAINTENANCE; ACTIVATION; INDUCTION; AUTOPHAGY;

D O I：

10.3389/fonc.2020.00311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. Recent studies have shown that cancer stem cells (CSCs) are present in ESCC, are thought to lead to aggressive tumor behavior and the prognosis. The CXC chemokine receptor 4 (CXCR4), is regarded as a putative CSCs marker in various malignancies. Here, we demonstrate that CXCR4 played a key role in ESCC progression and CXCR4 positive ESCC cells possessed stem-like properties. Furthermore, the anti-malarial agent chloroquine (CQ) targeted CXCR4-positive ESCC cells via STAT3 pathway. Therefore, CQ with anti-CSCs effects may be an effective adjunct to current ESCC chemotherapy regimens.

引用

页数：9

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