Diffusion Tensor Imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits

被引：75
作者：
Bohanna, India [4 ,5 ]
Georgiou-Karistianis, Nellie [1 ]
Sritharan, Anusha [1 ]
Asadi, Hamed [4 ,5 ]
Johnston, Leigh [2 ,5 ]
Churchyard, Andrew [3 ]
Egan, Gary [4 ,5 ]
机构：
[1] Monash Univ, Sch Psychol & Psychiat, Expt Neuropsychol Res Unit, Clayton, Vic 3800, Australia
[2] Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3052, Australia
[3] Monash Med Ctr, Dept Neurol, Clayton, Vic 3168, Australia
[4] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia
[5] Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic, Australia
来源：
BRAIN IMAGING AND BEHAVIOR | 2011年 / 5卷 / 03期
基金：
英国医学研究理事会;
关键词：
Huntington's disease; Diffusion tensor imaging; White matter; Tract-based spatial statistics; Corpus callosum; MINI-MENTAL STATE; CEREBRAL-CORTEX; MICROGLIAL ACTIVATION; AXONAL-TRANSPORT; BRAIN ATROPHY; OPTIC-NERVE; IN-VIVO; CONNECTIONS; VOLUME; IRON;
D O I：
10.1007/s11682-011-9121-8
中图分类号：
R445 [影像诊断学];
学科分类号：
100207 ;
摘要：
White matter (WM) degeneration is an important feature of Huntington's disease (HD) neuropathology. To investigate WM degeneration we used Diffusion Tensor Imaging and Tract-Based Spatial Statistics to compare Fractional Anisotropy, Mean Diffusivity (MD), parallel diffusivity and perpendicular diffusivity (lambda aSyen) in WM throughout the whole brain in 17 clinically diagnosed HD patients and 16 matched controls. Significant WM diffusivity abnormalities were identified primarily in the corpus callosum (CC) and external/extreme capsules in HD patients compared to controls. Significant correlations were observed between motor symptoms and MD in the CC body, and between global cognitive impairment and lambda aSyen in the CC genu. Probabilistic tractography from these regions revealed degeneration of functionally relevant interhemispheric WM tracts. Our findings suggest that WM degeneration within interhemispheric pathways plays an important role in the deterioration of cognitive and motor function in HD patients, and that improved understanding of WM pathology early in the disease is required.
引用
收藏
页码：171 / 180
页数：10
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