Cytochrome P450 isoenzymes - Importance for the internist

被引:23
作者
Kerremans, ALM
机构
[1] Department of Internal Medicine, Elkerliek Hospital, 5700 AB Helmond
关键词
cytochrome P450 isoenzymes; drug metabolism; drug interactions;
D O I
10.1016/0300-2977(96)00002-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The studies with CYP isoenzymes give hope that in the near future it will be possible to predict the clinical pharmacokinetics of-drugs, if their oxidation can be assigned to the activity of one or well-characterized CYP isoenyzmes (or if metabolism is catalyzed by other well-studied enzymes). This strategy will reduce animal experimentation. Interindividual variability in drug metabolism translates into variability in drug efficacy and toxicity. Establishing the status of-drug-metabolizing enzymes will therefore assist in making predictions of pharmacologic and toxicologic responses to drugs. Many clinically relevant drug-drug interactions can now be readily rationalized in terms of the substrate and inhibitor specificities of individual human CYP isoenzymes. The next 5 years should reveal whether selective inhibitors of xenobiotic-metabolizing CYP's can be used therapeutically in the treatment or prevention of cancer and various endocrine disorders, in analogy to the use of influencing steroidogenic CYP's.
引用
收藏
页码:237 / 243
页数:9
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