Endotoxin: The uninvited guest

被引：302
作者：
Gorbet, MB
Sefton, MV
机构：
[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada
[2] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada
[3] McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L7, Canada
来源：
BIOMATERIALS | 2005年 / 26卷 / 34期
关键词：
endotoxin; biomaterials; cytokines; LPS;
D O I：
10.1016/j.biomaterials.2005.04.063
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In the laboratory environment where biomaterials are synthesized and their biocompatibility assessed, we find that endotoxin contamination is hard to avoid and must not be ignored. In those relatively few cases where endotoxin was known to be present, it has been clearly shown that endotoxin call significantly affect the biological response observed and hence confound any effect of the material. This short review explains what endotoxin is, how to test for it and remove it and what its effect on the biological response to biomaterials is. We advocate routine testing of endotoxin on biomaterials and of reagents used in experimental evaluation of biomaterials and this should be the responsibility of every scientist to ensure the validity of any biomaterial study. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6811 / 6817
页数：7
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