Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands

被引：110

作者：

Andre, Vania ^{[2
]}

Hardeman, Andrew ^{[1
]}

Halasz, Ivan ^{[3
]}

Stein, Robin S. ^{[4
]}

Jackson, Graham J. ^{[5
]}

Reid, David G. ^{[1
]}

Duer, Melinda J. ^{[1
]}

Curfs, Caroline ^{[6
]}

Teresa Duarte, M. ^{[2
]}

Friscic, Tomislav ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Tecn Lisboa, Inst Super Tecn, Ctr Quim Estrutural, P-1100 Lisbon, Portugal

[3] Univ Zagreb, Fac Sci, Dept Chem, Zagreb 41000, Croatia

[4] Bruker UK Ltd, Coventry CV4 9GH, W Midlands, England

[5] Univ Cape Town, Dept Chem, ZA-7700 Rondebosch, South Africa

[6] ESRF ID31, Grenoble, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 34期

基金：

英国生物技术与生命科学研究理事会;

关键词：

bismuth; mechanochemistry; metallodrugs; structure elucidation; sustainable chemistry; MECHANOCHEMICAL SYNTHESIS; STEPWISE MECHANISM; COCRYSTAL; COMPLEXES; REACTIVITY; FRAMEWORKS; CHEMISTRY;

D O I：

10.1002/anie.201103171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ground out: Mechanochemical methods gave the pharmaceutical ingredient bismuth subsalicylate, as well as bismuth disalicylate and trisalicylate directly from bismuth oxide. Structure determination by powder X-ray diffraction gave the first structure of a bismuth salicylate without auxiliary organic ligands (see picture: Bi yellow, O red, C gray, two salicylate ion coordination modes are shown in purple and green). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7858 / 7861

页数：4

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