Effects of naloxone on the long-term potentiation of EPSPs from the pathway of Schaffer collateral to CA1 region of hippocampus in aged rats with declined memory

被引：10

作者：

Zhao, H ^{[1
]}

Xu, H ^{[1
]}

Xu, XH ^{[1
]}

机构：

[1] Shantou Univ, Dept Forens Med, Coll Med, Shantou 515031, Guangdong, Peoples R China

来源：

BRAIN RESEARCH | 2004年 / 996卷 / 01期

关键词：

naloxone; excitatory postsynaptic potential; hippocampal slice; memory; aging;

D O I：

10.1016/j.brainres.2003.10.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morris water maze (MWM) was employed to distinguish the aged rats with declined memory to investigate the effect of naloxone on the synaptic plasticity of hippocampus in declined memory aged rats. After administration with naloxone for 7 days, LTP of excitatory postsynaptic potentials (EPSPs) from Schaffer collateral to CAl region was recorded. The results showed that the maintenance of LTP of EPSPs from Schaffer collateral to CAl subfield in isolate hippocampal brain slice was prolonged by naloxone with improved Morris water maze performance and reduced threshold of EPSPs. It is suggested that naloxone can improve learning and memory through enhancement of the synaptic plasticity of hippocampus in aged rats with declined memory. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：111 / 116

页数：6

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