Synthesis of methyl 7-aryl-6-(2-thenoyl)-4,7-dihydro-tetrazolo[1,5-a]pyrimidine-5-carboxylates and their reaction with hydrazine hydrate

被引：7

作者：

Gein, V. L. ^{[1
]}

Mishunin, V. V. ^{[1
]}

Tsyplyakova, E. P. ^{[2
]}

Vakhrin, M. I. ^{[1
]}

Slepukhin, P. A. ^{[3
]}

机构：

[1] Fed Hlth & Social Dev Agcy, Perm State Pharmaceut Acad, Perm 614990, Russia

[2] Russian State Univ Trade & Econ, Perm Inst Branch, Perm 614070, Russia

[3] Russian Acad Sci, Postovskii Inst Organ Synth, Ural Div, Ekaterinburg 620219, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 47卷 / 07期

关键词：

Aromatic Aldehyde; Hydrazine Hydrate; Ylate; Pyridazin; Ketone Carbonyl Group;

D O I：

10.1134/S1070428011070189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fusion of methyl 4-(2-thienyl)-2,4-dioxobutanoate with 1H-tetrazol-5-amine monohydrate and aromatic aldehyde gave methyl 7-aryl-6-(2-thenoyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates which reacted with an equimolar amount of hydrazine hydrate at 180-190A degrees C under solvent-free conditions to produce 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1',5': 1,2]pyrimido[4,5-d]pyridazin-5(6H)-ones.

引用

页码：1077 / 1082

页数：6