Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation

被引：49

作者：

Xie, Cheng ^{[1
]}

Yan, Wei ^{[2
]}

Quan, Runze ^{[1
]}

Chen, Chaoyue ^{[1
]}

Tu, Lei ^{[1
]}

Hou, Xiaohua ^{[1
]}

Fu, Yu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Dept Gastroenterol, Tongji Med Coll, 1277 Jiefang Rd, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol, Tongji Med Coll, Wuhan 430030, Peoples R China

来源：

CYTOKINE | 2020年 / 127卷

基金：

中国国家自然科学基金;

关键词：

Interleukin-38; Inflammatory bowel diseases; Cytokines; GENE-CLUSTER; FAMILY; IL-38; IDENTIFICATION; ASSOCIATION; CYTOKINES; ARTHRITIS; PSORIASIS; MEMBERS;

D O I：

10.1016/j.cyto.2019.154963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There has been no report investigating the role of IL-38 in inflammatory bowel diseases (IBD). Therefore, we investigated the expression of IL-38 in IBD patients and its role in regulating intestinal inflammation. The levels of IL-38 were significantly elevated in the intestine of IBD patients and DSS-induced colitis mice. Immunofluorescence analysis revealed that B cell, not macrophage or T cell, was the source of IL-38 in the intestine. We found that rIL-38 treatment significantly attenuated DSS-induced colitis, including alleviation of weight loss, disease activity index, macroscopic changes and histological damage of colon, along with lower levels of IL-1 beta and TNF-alpha. In vitro, rIL-38 significantly decreased the expression of proinflammatory cytokines in LPS-stimulated RAW 264.7 cells and BMDM. This is the first study suggesting that IL-38 may have a protective effect in IBD, which inhibits the production of proinflammatory cytokines from macrophages. IL-38 may represent a promising therapeutic strategy in IBD.

引用

页数：10

共 33 条

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