Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease

被引：65

作者：

Kamekura, Ryuta ^{[1
,2
]}

Takano, Kenichi ^{[2
]}

Yamamoto, Motohisa ^{[3
]}

Kawata, Koji ^{[1
]}

Shigehara, Katsunori ^{[1
]}

Jitsukawa, Sumito ^{[1
,2
]}

Nagaya, Tomonori ^{[2
]}

Ito, Fumie ^{[1
,2
]}

Sato, Akinori ^{[1
]}

Ogasawara, Noriko ^{[2
]}

Tsubomatsu, Chieko ^{[2
]}

Takahashi, Hiroki ^{[3
]}

Nakase, Hiroshi ^{[4
]}

Himi, Tetsuo ^{[2
]}

Ichimiya, Shingo ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Res Inst Frontier Med, Dept Human Immunol,Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan

[2] Sapporo Med Univ, Sch Med, Dept Otolaryngol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[3] Sapporo Med Univ, Sch Med, Dept Rheumatol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[4] Sapporo Med Univ, Sch Med, Dept Gastroenterol & Hepatol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2017年 / 199卷 / 08期

关键词：

DACRYOADENITIS; CRITERIA; IGG4;

D O I：

10.4049/jimmunol.1601507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IgG4-related disease (IgG4-RD) is a newly recognized systemic chronic fibroinflammatory disease. However, the pathogenesis of IgG4-RD remains unknown. To determine the pathophysiologic features of IgG4-RD, we examined T follicular helper (Tfh) cells in lesions and blood from patients with IgG4-RD. Patients with IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) showed increased infiltration of Tfh cells highly expressing programmed death 1 and ICOS in submandibular glands. Tfh cells from IgG4-DS submandibular glands had higher expression of B cell lymphoma 6 and a greater capacity to help B cells produce IgG4 than did tonsillar Tfh cells. We also found that the percentage of programmed death 1 hi circulating Tfh cells in IgG4-DS patients was higher than that in healthy volunteers and was well correlated with clinical parameters. Our findings indicate that anomalous Tfh cells in tissue lesions of IgG4-RD have features distinct from those in lymphoid counterparts or blood and potentially regulate local IgG4 production in IgG4-RD.

引用

页码：2624 / 2629

页数：6

共 23 条

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