Sizing up targets with nanoparticles

被引:63
作者
Minchin, Rod [1 ,2 ]
机构
[1] Univ Queensland, Ctr Preclin Drug Dev, Brisbane, Qld, Australia
[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia
关键词
D O I
10.1038/nnano.2007.433
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Nanoparticles have many potential medical applications but their behaviour in the body is poorly understood. New studies in mice show that particles that don't have targeting molecules attached can selectively enter certain organs solely on the basis of their charge and size.
引用
收藏
页码:12 / 13
页数:2
相关论文
共 5 条
  • [1] BALOGH L, 2007, NANOMED NANOTECHNOL
  • [2] Immunological properties of engineered nanomaterials
    Dobrovolskaia, Marina A.
    Mcneil, Scott E.
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (08) : 469 - 478
  • [3] PEGylated nanoparticles for biological and pharmaceutical applications
    Otsuka, H
    Nagasaki, Y
    Kataoka, K
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (03) : 403 - 419
  • [4] Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    Owens, DE
    Peppas, NA
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 307 (01) : 93 - 102
  • [5] An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution
    Sun, XK
    Rossin, R
    Turner, JL
    Becker, ML
    Joralemon, MJ
    Welch, MJ
    Wooley, KL
    [J]. BIOMACROMOLECULES, 2005, 6 (05) : 2541 - 2554