Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites

被引：13

作者：

Berrue, Fabrice

Withers, Sydnor T.

Haltli, Brad

Withers, Jo

Kerr, Russell G. ^{[1
]}

机构：

[1] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Chem, Charlottetown, PE C1A 4P3, Canada

来源：

MARINE DRUGS | 2011年 / 9卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

chemical screening; coral-associated bacteria; UPLC/MS; gorgonian coral; CORAL ERYTHROPODIUM-CARIBAEORUM; LOVE ET-AL; NATURAL-PRODUCTS; MASS-SPECTROMETRY; DRUGS; BACTERIA; SPONGE; PHARMACEUTICALS; PHOTOBACTERIUM; DITERPENOIDS;

D O I：

10.3390/md9030369

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites.

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收藏

页码：369 / 381

页数：13

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