Bioaffinitive and nanosized polymeric micelles based on a reactive block copolymer

被引：14
|
作者：
Hu, YC [1 ]
Pan, CY [1 ]
机构：
[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2005年 / 26卷 / 12期
关键词：
biological applications of polymers; block copolymers; glucosamine; micelles; self-assembly;
D O I：
10.1002/marc.200500101
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Bio-affinitive, nanosized polymeric micelles with glucosamine in their corona have a specific interaction with Concanavalin A. They are prepared by a substitution reaction of p-nitrophenol groups in the poly(p-nitrophenyl acrylate) (PNPA) corona of stable micelles with glucosamine. The nanosized, stable, and reactive micelles are formed by self-assembly of the diblock copolymer, poly(p-nitrophenyl acrylate)-block-polystyrene (PNPA-b-PSt) in nitromethane, followed by a shell cross-Linking reaction. This method may be useful in the preparation of targeted drugs.
引用
收藏
页码：968 / 972
页数：5
相关论文
共 50 条
  • [41] Formation of block copolymer micelles and reverse micelles in aqueous solution
    Bütün, Vural
    Armes, Steven P.
    B'Minghab, Norman C.
    Tuzar, Zdenek
    American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 1999, 40 (02): : 261 - 262
  • [42] Surfactant micelles and block copolymer micelles: Similarities and differences.
    Nagarajan, R
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 97 - IEC
  • [43] The reactive polymeric micelle based on an aldehyde-ended poly(ethylene glycol)/poly(lactide) block copolymer
    Nagasaki, Y
    Okada, T
    Scholz, C
    Iijima, M
    Kato, M
    Kataoka, K
    MACROMOLECULES, 1998, 31 (05) : 1473 - 1479
  • [44] Nanosized Complexes of the Proteolytic Enzyme Serratiopeptidase with Cationic Block Copolymer Micelles Enhance the Proliferation and Migration of Human Cells
    Kamenova, Katya
    Prancheva, Anna
    Radeva, Lyubomira
    Yoncheva, Krassimira
    Zaharieva, Maya M.
    Najdenski, Hristo M.
    Petrov, Petar D.
    PHARMACEUTICS, 2024, 16 (08)
  • [45] Reactive block copolymer scaffolds
    Li, Ronald C.
    Hwang, Jungyeon
    Maynard, Heather D.
    CHEMICAL COMMUNICATIONS, 2007, (35) : 3631 - 3633
  • [46] Design of block-copolymer-based micelles for active and passive targeting
    Lebouille, Jerome G. J. L.
    Leermakers, Frans A. M.
    Stuart, Martien A. Cohen
    Tuinier, Remco
    PHYSICAL REVIEW E, 2016, 94 (04)
  • [47] Crystallization and coalescence of block copolymer micelles in semicrystalline block copolymer/amorphous homopolymer blends
    Xu, JT
    Jin, W
    Liang, GD
    Fan, ZQ
    POLYMER, 2005, 46 (05) : 1709 - 1716
  • [48] Block-copolymer micelles with a interpolyelectrolyte crown
    Lysenko, E. A.
    Bilan, R. S.
    Chelushkin, P. S.
    POLYMER SCIENCE SERIES C, 2017, 59 (01) : 35 - 48
  • [49] Dynamics of block copolymer micelles in aqueous solution
    Waton, G
    Michels, B
    Zana, R
    MACROMOLECULES, 2001, 34 (04) : 907 - 910
  • [50] Metallo-supramolecular block copolymer micelles
    Gohy, Jean-Francois
    COORDINATION CHEMISTRY REVIEWS, 2009, 253 (17-18) : 2214 - 2225
12345