Bioaffinitive and nanosized polymeric micelles based on a reactive block copolymer

被引：14
|
作者：
Hu, YC [1 ]
Pan, CY [1 ]
机构：
[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2005年 / 26卷 / 12期
关键词：
biological applications of polymers; block copolymers; glucosamine; micelles; self-assembly;
D O I：
10.1002/marc.200500101
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Bio-affinitive, nanosized polymeric micelles with glucosamine in their corona have a specific interaction with Concanavalin A. They are prepared by a substitution reaction of p-nitrophenol groups in the poly(p-nitrophenyl acrylate) (PNPA) corona of stable micelles with glucosamine. The nanosized, stable, and reactive micelles are formed by self-assembly of the diblock copolymer, poly(p-nitrophenyl acrylate)-block-polystyrene (PNPA-b-PSt) in nitromethane, followed by a shell cross-Linking reaction. This method may be useful in the preparation of targeted drugs.
引用
收藏
页码：968 / 972
页数：5
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