Electrochemical study of some non-steroidal anti-inflammatory drugs: solvent effect and antioxidant activity

被引：11
作者：
Tsopelas, Fotios [1 ,2 ]
Ochsenkuehn-Petropoulou, Maria [1 ]
Zikos, Nikos [1 ,3 ]
Spyropoulou, Eleni [2 ]
Andreadou, Ioanna [2 ]
Tsantili-Kakoulidou, Anna [2 ]
机构：
[1] Natl Tech Univ Athens, Sch Chem Engn, Inorgan & Analyt Chem Lab, GR-15773 Athens, Greece
[2] Univ Athens, Sch Pharm, Lab Pharmaceut Chem, GR-15771 Athens, Greece
[3] Univ Athens, Sch Chem, Lab Ind Chem, GR-15771 Athens, Greece
来源：
JOURNAL OF SOLID STATE ELECTROCHEMISTRY | 2011年 / 15卷 / 06期
关键词：
Voltammetry; Non-steroidal anti-inflammatory drugs; Oxicams; Solvent polarity effect; Antioxidant activity; DPPH; VOLTAMMETRIC DETERMINATION; ORGANOTIN COMPOUNDS; CYCLIC VOLTAMMETRY; ASCORBIC-ACID; HUMAN SERUM; OXIDATION; CAPACITY; BEHAVIOR; DERIVATIVES; SEPARATION;
D O I：
10.1007/s10008-010-1165-y
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
The electrochemical behavior of 12 non-steroidal anti-inflammatory drugs (NSAIDs) was studied by means of cyclic voltammetry at a glassy carbon electrode. The underlying solvent had a considerable effect to the oxidation potentials of the investigated NSAIDs due to the alteration of their polar intermediates' solvation. Oxicams were more capable of electrochemical oxidation, and the influence of both specific and non-specific solute-solvent interactions in their reactivity was confirmed by means of Kamlet-Taft's analysis. Oxicams were further studied by chronoamperometry at the potentials of 300, 500, and 800 mV. The results obtained by the employed electroanalytical techniques were compared with the reactivity of oxicams towards 1,1- diphenyl-2-dipicrylhydrazyl (DPPH). The study showed a correlation of oxicams' amperometric signal at 800 mV with their absolute reaction rate, z with DPPH.
引用
收藏
页码：1099 / 1108
页数：10
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