A method for the automatic characterization of bone architecture in 3D mice microtomographic images

被引：54
作者：
Martín-Badosa, E
Elmoutaouakkil, A
Nuzzo, S
Amblard, D
Vico, L
Peyrin, F
机构：
[1] European Synchrotron Radiat Facil, F-38043 Grenoble, France
[2] Univ Barcelona, Dept FAO, Lab Opt, E-08028 Barcelona, Spain
[3] CREATIS, CNRS, UMR 5515, F-69621 Villeurbanne, France
[4] CHU St Etienne, LBBTO, INSERM, Equipe Mixte E9901, F-42023 St Etienne, France
来源：
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 2003年 / 27卷 / 06期
关键词：
computed microtomography; bone microarchitecture; mice; osteoporosis; trabecular and cortical bone; 3D analysis; small animal imaging;
D O I：
10.1016/S0895-6111(03)00031-4
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We developed an automatic method to characterize mice bone architecture from three-dimensional (3D) microtomographic images. The distal metaphyses of the femur of mice were imaged using 3D synchrotron radiation microtomography at the European Synchrotron Radiation Facility (ID19) with a voxel size of 6.65 mum. Within each reconstructed volume, a region of interest was defined and trabecular and cortical bones were automatically separated. Then, 3D morphologic and topologic model-independent parameters quantifying the 3D bone architecture were computed in both regions. The technique was applied to study the response of the C57BL/6J@Ico strain of mice submitted to a model of bone loss by hind limb unloading produced by tail-suspension. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：447 / 458
页数：12
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