New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5

被引：60

作者：

Liu, Lu ^{[1
,2
]}

Feng, Yu ^{[1
,2
]}

Zhang, Xiaoxia ^{[1
,2
]}

McNally, Alan ^{[5
]}

Zong, Zhiyong ^{[1
,2
,3
,4
]}

机构：

[1] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu, Sichuan, Peoples R China

[2] State Key Lab Biotherapy, Div Infect Dis, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Infect Control, Chengdu, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp, Ctr Pathogen Res, Chengdu, Sichuan, Peoples R China

[5] Univ Birmingham, Coll Med & Dent Sci, Inst Microbiol & Infect, Birmingham, W Midlands, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 12期

基金：

中国国家自然科学基金;

关键词：

colistin; resistance; plasmids; Escherichia coli; Enterobacteriaceae; BETA-LACTAMASE; PLASMID;

D O I：

10.1128/AAC.01757-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3, and a carbapenemase gene, bla(NDM-5). mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.

引用

页数：4

共 15 条

[11]

Szuplewska Magdalena, 2014, Mob Genet Elements, V4, P1

[12] Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016 [J].

Xavier, B. B. ;

Lammens, C. ;

Ruhal, R. ;

Kumar-Singh, S. ;

Butaye, P. ;

Goossens, H. ;

Malhotra-Kumar, S. .

EUROSURVEILLANCE, 2016, 21 (27) :8-13

[13] blaNDM-5 Carried by an IncX3 Plasmid in Escherichia coli Sequence Type 167 [J].

Yang, Ping ;

Xie, Yi ;

Feng, Ping ;

Zong, Zhiyong .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (12) :7548-7552

[14] Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli [J].

Yin, Wenjuan ;

Li, Hui ;

Shen, Yingbo ;

Liu, Zhihai ;

Wang, Shaolin ;

Shen, Zhangqi ;

Zhang, Rong ;

Walsh, Timothy R. ;

Shen, Jianzhong ;

Wang, Yang .

MBIO, 2017, 8 (03)

[15] IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage [J].

Zhao, Feifei ;

Feng, Yu ;

Lu, Xiaoju ;

McNally, Alan ;

Zong, Zhiyong .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (02)

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