New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and blaNDM-5

被引：60
作者：
Liu, Lu [1 ,2 ]
Feng, Yu [1 ,2 ]
Zhang, Xiaoxia [1 ,2 ]
McNally, Alan [5 ]
Zong, Zhiyong [1 ,2 ,3 ,4 ]
机构：
[1] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu, Sichuan, Peoples R China
[2] State Key Lab Biotherapy, Div Infect Dis, Chengdu, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Infect Control, Chengdu, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Ctr Pathogen Res, Chengdu, Sichuan, Peoples R China
[5] Univ Birmingham, Coll Med & Dent Sci, Inst Microbiol & Infect, Birmingham, W Midlands, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 12期
基金：
中国国家自然科学基金;
关键词：
colistin; resistance; plasmids; Escherichia coli; Enterobacteriaceae; BETA-LACTAMASE; PLASMID;
D O I：
10.1128/AAC.01757-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3, and a carbapenemase gene, bla(NDM-5). mcr-3 is a new variant (mcr-3.5) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a TnAs3-like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.
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页数：4
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