S100A4 expression and prognosis of gastric cancer: a meta-analysis

被引：6
作者：
Wang, Y. [1 ]
Zhou, L. -B. [1 ]
Li, X. -H. [2 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 2, Dept Gen Surg, Hefei, Peoples R China
[2] Shanghai Eighth Peoples Hosp, Dept Digest Med, Shanghai, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 04期
关键词：
S100A4; Prognosis; Gastric cancer; Meta-analysis; FAMILY;
D O I：
10.4238/2014.December.12.1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95%CI). A total of 7 eligible studies that included 1257 gastric cancer patients were analyzed. We did not find a prognostic value for S100A4 in gastric cancer (HR = 1.48, 95% CI = 0.77 to 2.82, P = 0.24). In conclusion, the present study indicated that S100A4 expression level is not a prognostic factor for gastric cancer.
引用
收藏
页码：10398 / 10403
页数：6
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