Cleavage agents for soluble oligomers of amyloid β peptides

被引：98

作者：

Suh, Junghun ^{[1
]}

Yoo, Sang Ho ^{[1
]}

Kim, Min Gyum ^{[1
]}

Jeong, Keunhong ^{[1
]}

Ahn, Jae Young ^{[1
]}

Kim, Myoung-Soon ^{[1
]}

Chae, Pil Seok ^{[1
]}

Lee, Tae Yeon ^{[1
]}

Lee, Jaehwa ^{[1
]}

Lee, Jeongkuk ^{[1
]}

Jang, Yun Ah ^{[1
]}

Ko, Eun Hwa ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 37期

关键词：

Alzheimer's disease; amyloid beta peptides; combinatorial chemistry; drug design; peptide cleavage;

D O I：

10.1002/anie.200702399

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Clearing the mind: Peptide-cleaving agents for amyloid β-42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10-tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7064 / 7067

页数：4

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