Cleavage agents for soluble oligomers of amyloid β peptides

被引：97

作者：

Suh, Junghun ^{[1
]}

Yoo, Sang Ho ^{[1
]}

Kim, Min Gyum ^{[1
]}

Jeong, Keunhong ^{[1
]}

Ahn, Jae Young ^{[1
]}

Kim, Myoung-Soon ^{[1
]}

Chae, Pil Seok ^{[1
]}

Lee, Tae Yeon ^{[1
]}

Lee, Jaehwa ^{[1
]}

Lee, Jeongkuk ^{[1
]}

Jang, Yun Ah ^{[1
]}

Ko, Eun Hwa ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 37期

关键词：

Alzheimer's disease; amyloid beta peptides; combinatorial chemistry; drug design; peptide cleavage;

D O I：

10.1002/anie.200702399

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Clearing the mind: Peptide-cleaving agents for amyloid β-42 (Aβ42) oligomers (see scheme), the intermediate neurotoxic species in the pathology of Alzheimer's disease, have been obtained from a combinatorial library built using the CoIII complex of 1,4,7,10-tetraazacyclododecane as the reaction center. Effective cleavage of the Aβ42 oligomers occurs at submicromolar concentrations of the agents. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7064 / 7067

页数：4

共 50 条

[1] Cleavage agents for soluble oligomers of human islet amyloid polypeptide
Suh, Junghun
Chei, Woo Suk
Lee, Tae Yeon
Kim, Min Gyum
Yoo, Sang Ho
Jeong, Keunhong
Ahn, Jae Young
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2008, 13 (05): : 693 - 701
[2] Cleavage agents for soluble oligomers of human islet amyloid polypeptide
Junghun Suh
Woo Suk Chei
Tae Yeon Lee
Min Gyum Kim
Sang Ho Yoo
Keunhong Jeong
Jae Young Ahn
JBIC Journal of Biological Inorganic Chemistry, 2008, 13 : 693 - 701
[3] Targeting Soluble Amyloid Oligomers in Alzheimer's Disease through Disordered Prion Peptides
Levine, Zachary A.
BIOPHYSICAL JOURNAL, 2019, 116 (03) : 495A - 495A
[4] Amyloid Peptide Conformations In Soluble Oligomers
Digambaranath, Jyothi L.
Block, Ben P.
Campbell, Tyler
Dang, Loan
Dembinska, Monika
Williams, Kim K.
Finke, John M.
BIOPHYSICAL JOURNAL, 2009, 96 (03) : 88A - 88A
[5] Surface Assay for Specific Detection of Soluble Amyloid Oligomers Utilizing Pronucleon Peptides Instead of Antibodies
Matveeva, Evgenia G.
Moll, Jonathan R.
Khan, Mariam M.
Thompson, Richard B.
Cliff, Richard O.
ACS CHEMICAL NEUROSCIENCE, 2017, 8 (06): : 1213 - 1221
[6] Soluble amyloid oligomers: a common cause of neurodegeneration?
Senior, K
LANCET NEUROLOGY, 2003, 2 (06): : 330 - 330
[7] Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
Shin, Thuzar M.
Isas, J. Mario
Hsieh, Chia-Ling
Kayed, Rakez
Glabe, Charles G.
Langen, Ralf
Chen, Jeannie
MOLECULAR NEURODEGENERATION, 2008, 3 (1)
[8] Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
Thuzar M Shin
J Mario Isas
Chia-Ling Hsieh
Rakez Kayed
Charles G Glabe
Ralf Langen
Jeannie Chen
Molecular Neurodegeneration, 3
[9] Structures of soluble amyloid oligomers from computer simulations
Melquiond, Adrien
Mousseau, Normand
Derreumaux, Philippe
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2006, 65 (01) : 180 - 191
[10] Structural studies of soluble oligomers of the Alzheimer β-amyloid peptide
Huang, THJ
Yang, DS
Plaskos, NP
Go, S
Yip, CM
Fraser, PE
Chakrabartty, A
JOURNAL OF MOLECULAR BIOLOGY, 2000, 297 (01) : 73 - 87

← 1 2 3 4 5 →