Cellular Senescence: Defining a Path Forward

被引：2015

作者：

Gorgoulis, Vassilis ^{[1
,22
,27
,28
]}

Adams, Peter D. ^{[2
,29
,30
]}

Alimonti, Andrea ^{[3
,31
,32
,33
]}

Bennett, Dorothy C. ^{[4
]}

Bischof, Oliver ^{[5
]}

Bishop, Cleo ^{[6
]}

Campisi, Judith ^{[7
]}

Collado, Manuel ^{[8
]}

Evangelou, Konstantinos ^{[1
]}

Ferbeyre, Gerardo ^{[10
,11
]}

Gil, Jesus ^{[12
,34
]}

Hara, Eiji ^{[13
]}

Krizhanovsky, Valery ^{[14
]}

Jurk, Diana ^{[15
]}

Maier, Andrea B. ^{[16
,35
]}

Narita, Masashi ^{[17
]}

Niedernhofer, Laura ^{[18
]}

Passos, Joao F. ^{[15
]}

Robbins, Paul D. ^{[18
]}

Schmitt, Clemens A. ^{[19
,20
,36
,37
]}

Sedivy, John ^{[21
]}

Vougas, Konstantinos ^{[22
]}

von Zglinicki, Thomas ^{[23
]}

Zhou, Daohong ^{[24
]}

Serrano, Manuel ^{[9
,25
]}

Demaria, Marco ^{[26
]}

机构：

[1] Univ Athens, Med Sch, Dept Histol & Embryol, Mol Carcinogenesis Grp, Athens, Greece

[2] Univ Glasgow, Inst Canc Sci, Glasgow G61 1BD, Lanark, Scotland

[3] Oncol Inst Southern Switzerland, IOR, Bellinzona, Switzerland

[4] St Georges Univ London, Mol & Clin Sci Res Inst, London SW17 0RE, England

[5] Inst Pasteur, Lab Nucl Org & Oncogenesis, Dept Cell Biol & Infect, INSERM,U993, Paris, France

[6] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Cell Biol & Cutaneous Res, 4 Newark St, London E1 2AT, England

[7] Buck Inst Res Aging, Novato, CA USA

[8] Clin Univ Hosp CHUS, Hlth Res Inst Santiago De Compostela IDIS, Santiago De Compostela, Spain

[9] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[10] Univ Montreal, Dept Biochem, Fac Med, Montreal, PQ, Canada

[11] CRCHUM, Montreal, PQ, Canada

[12] MRC London Inst Med Sci LMS, Cane Rd, London, England

[13] Osaka Univ, Microbial Dis Res Inst, Dept Mol Microbiol, Osaka, Japan

[14] Weizmann Inst Sci, Dept Mol Cell Biol, Rehovot, Israel

[15] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN USA

[16] Vrije Univ, Amsterdam Movement Sci, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam, Netherlands

[17] Univ Cambridge, Li Ka Shing Ctr, Canc Res UK Cambridge Inst, Cambridge CB2 0RE, England

[18] Univ Minnesota, Inst Biol Aging & Metab, Minneapolis, MN USA

[19] Charite Univ Med Ctr, Dept Hematol Oncol & Tumor Immunol, Virchow Campus, Berlin, Germany

[20] Mol Krebsforschungszentrum, Berlin, Germany

[21] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA

[22] Acad Athens, Biomed Res Fdn, Athens, Greece

[23] Newcastle Univ, Inst Cell & Mol Biol, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[24] Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA

[25] BIST, Inst Res Biomed IRB Barcelona, Barcelona, Spain

[26] Univ Groningen RUG, UMCG, ERIBA, Groningen, Netherlands

[27] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Inst Canc Sci, Manchester, Lancs, England

[28] Univ Athens, Med Sch, Ctr New Biotechnol & Precis Med, Athens, Greece

[29] CRUK Beatson Inst, Glasgow G61 1BD, Lanark, Scotland

[30] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

[31] Univ Svizzera Italiana, Fac Biomed Sci, Lugano, Switzerland

[32] Univ Padua, Dept Med, Padua, Italy

[33] Veneto Inst Mol Med, Padua, Italy

[34] Imperial Coll London, Fac Med, ICS, Cane Rd, London, England

[35] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, Melbourne, Vic, Australia

[36] Max Delbruck Ctr Mol Med Helmholtz Assoc, Berlin, Germany

[37] Johannes Kepler Univ Linz, Dept Hematol & Oncol, Kepler Univ Hosp, Linz, Austria

来源：

CELL | 2019年 / 179卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE RESPONSE; CHROMATIN LANDSCAPE; OXIDATIVE STRESS; DARK SIDE; CELLS; CANCER; P53; MITOCHONDRIA; EXPRESSION;

D O I：

10.1016/j.cell.2019.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

引用

页码：813 / 827

页数：15

共 153 条

[1]

Abdelaal T., 2019, BIOINFORMATICS

[2] A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].

Acosta, Juan Carlos ;

Banito, Ana ;

Wuestefeld, Torsten ;

Georgilis, Athena ;

Janich, Peggy ;

Morton, Jennifer P. ;

Athineos, Dimitris ;

Kang, Tae-Won ;

Lasitschka, Felix ;

Andrulis, Mindaugas ;

Pascual, Gloria ;

Morris, Kelly J. ;

Khan, Sadaf ;

Jin, Hong ;

Dharmalingam, Gopuraja ;

Snijders, Ambrosius P. ;

Carroll, Thomas ;

Capper, David ;

Pritchard, Catrin ;

Inman, Gareth J. ;

Longerich, Thomas ;

Sansom, Owen J. ;

Aznar Benitah, Salvador ;

Zender, Lars ;

Gil, Jesus .

NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221

[3] Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? [J].

Ademowo, O. S. ;

Dias, H. K. I. ;

Burton, D. G. A. ;

Griffiths, H. R. .

BIOGERONTOLOGY, 2017, 18 (06) :859-879

[4] An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria [J].

Andressoo, Jaan-Olle ;

Mitchell, James R. ;

de Wit, Jan ;

Hoogstraten, Deborah ;

Volker, Marcel ;

Toussaint, Wendy ;

Speksnijder, Ewoud ;

Beems, Rudolph B. ;

van Steeg, Harry ;

Jans, Judith ;

de Zeeuw, Chris I. ;

Jaspers, Nicolaas G. J. ;

Raams, Anja ;

Lehmann, Alan R. ;

Vermeulen, Wim ;

Hoeijmakers, Jan H. J. ;

van der Horst, Gijsbertus T. J. .

CANCER CELL, 2006, 10 (02) :121-132

[5] Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging [J].

Baar, Marjolein P. ;

Brandt, Renata M. C. ;

Putavet, Diana A. ;

Klein, Julian D. D. ;

Derks, Kasper W. J. ;

Bourgeois, Benjamin R. M. ;

Stryeck, Sarah ;

Rijksen, Yvonne ;

van Willigenburg, Hester ;

Feijtel, Danny A. ;

van der Pluijm, Ingrid ;

Essers, Jeroen ;

van Cappellen, Wiggert A. ;

van IJcken, Wilfred F. ;

Houtsmuller, Adriaan B. ;

Pothof, Joris ;

de Bruin, Ron W. F. ;

Madl, Tobias ;

Hoeijmakers, Jan H. J. ;

Campisi, Judith ;

de Keizer, Peter L. J. .

CELL, 2017, 169 (01) :132-+

[6] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].

Baker, Darren J. ;

Wijshake, Tobias ;

Tchkonia, Tamar ;

LeBrasseur, Nathan K. ;

Childs, Bennett G. ;

van de Sluis, Bart ;

Kirkland, James L. ;

van Deursen, Jan M. .

NATURE, 2011, 479 (7372) :232-U112

[7] Reversal of human cellular senescence:: roles of the p53 and p16 pathways [J].

Beauséjour, CM ;

Krtolica, A ;

Galimi, F ;

Narita, M ;

Lowe, SW ;

Yaswen, P ;

Campisi, J .

EMBO JOURNAL, 2003, 22 (16) :4212-4222

[8] Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells [J].

Benhamed, Moussa ;

Herbig, Utz ;

Ye, Tao ;

Dejean, Anne ;

Bischof, Oliver .

NATURE CELL BIOLOGY, 2012, 14 (03) :266-+

[9] MicroRNAs miR-146a/b negatively modulate the senescence associated inflammatory mediators IL-6 and IL-8 [J].

Bhaumik, Dipa ;

Scott, Gary K. ;

Schokrpur, Shiruyeh ;

Patil, Christopher K. ;

Orjalo, Arturo V. ;

Rodier, Francis ;

Lithgow, Gordon J. ;

Campisi, Judith .

AGING-US, 2009, 1 (04) :402-411

[10] Quantitative identification of senescent cells in aging and disease [J].

Biran, Anat ;

Zada, Lior ;

Abou Karam, Paula ;

Vadai, Ezra ;

Roitman, Lior ;

Ovadya, Yossi ;

Porat, Ziv ;

Krizhanovsky, Valery .

AGING CELL, 2017, 16 (04) :661-671

← 1 2 3 4 5 6 7 8 9 10 →