Innate lymphoid cells in inflammatory bowel diseases

被引：52
作者：
Peters, C. P. [1 ]
Mjosberg, J. M. [2 ]
Bernink, J. H. [3 ]
Spits, H. [3 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[2] Karolinska Univ Hosp Huddinge, Karolinska Inst, CIM, Dept Med, F59, S-14186 Stockholm, Sweden
[3] Univ Amsterdam, Acad Med Ctr, Dept Celbiol & Histol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
来源：
IMMUNOLOGY LETTERS | 2016年 / 172卷
关键词：
Innate lymphoid cells; ILC; Crohn's disease; Ulcerative colitis; IBD; Anti-TNF; IFN-gamma; NATURAL-KILLER-CELLS; ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; INTERFERON-GAMMA PRODUCTION; TRANSCRIPTION FACTOR GATA3; ARYL-HYDROCARBON RECEPTOR; ULCERATIVE-COLITIS; T-CELLS; LAMINA-PROPRIA; CROHNS-DISEASE; DOUBLE-BLIND;
D O I：
10.1016/j.imlet.2015.10.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD. (C) 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：124 / 131
页数：8
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