Glycosphingolipids as Receptors for Non-Enveloped Viruses

被引：80

作者：

Taube, Stefan ^{[1
]}

Jiang, Mengxi ^{[1
]}

Wobus, Christiane E. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 04期

关键词：

non-enveloped virus; glycosphingolipid; receptor; calicivirus; rotavirus; polyomavirus; parvovirus; BLOOD GROUP ANTIGENS; HEMORRHAGIC-DISEASE VIRUS; HUMAN PARVOVIRUS B19; SIALIC-ACID-BINDING; MAJOR HISTOCOMPATIBILITY PROTEINS; ROTAVIRUS SPIKE PROTEIN; N-LINKED GLYCOPROTEIN; ERYTHROCYTE-P-ANTIGEN; NORWALK-LIKE VIRUS; FELINE-CALICIVIRUS;

D O I：

10.3390/v2041011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma-and parvovirus families.

引用

页码：1011 / 1049

页数：39

共 215 条

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