Importance of home study visit capacity in dementia studies

被引：29

作者：

Crane, Paul K. ^{[1
]}

Gibbons, Laura E. ^{[1
]}

McCurry, Susan M. ^{[2
]}

McCormick, Wayne ^{[1
]}

Bowen, James D. ^{[3
]}

Sonnen, Joshua ^{[4
]}

Keene, C. Dirk ^{[5
]}

Grabowski, Thomas ^{[6
]}

Montine, Thomas J. ^{[5
]}

Larson, Eric B. ^{[7
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA USA

[2] Univ Washington, Dept Psychosocial & Community Hlth, Seattle, WA 98195 USA

[3] Swedish Neurosci Inst, Dept Neurol, Multiple Sclerosis Ctr, Seattle, WA USA

[4] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[5] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[7] Grp Hlth Res Inst, Seattle, WA USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Home research study visits; Research clinic study visits; Missing data; Bias; Prospective studies; Cohort studies; Longitudinal studies; Inference; Dementia; Neuropathology; ALZHEIMERS-DISEASE; RISK; DIAGNOSIS; SAMPLE; HEALTH;

D O I：

10.1016/j.jalz.2015.10.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The importance of home research study visit capacity in Alzheimer's disease (AD) studies is unknown. Methods: All evaluations are from the prospective Adult Changes in Thought study. Based on analyses of factors associated with volunteering for a new in-clinic initiative, we analyzed AD risk factors and the relevance of neuropathologic findings for dementia comparing all data including home visits, and in-clinic data only. We performed bootstrapping to determine whether differences were greater than expected by chance. Results: Of the 1781 people enrolled during 1994-1996 with >= 1 follow-up, 1369 (77%) had inclinic data, covering 61% of follow-up time. In-clinic data resulted in excluding 76% of incident dementia and AD cases. AD risk factors and the relevance of neuropathologic findings for dementia were both different with in-clinic data. Discussion: Limiting data collection in AD studies to research clinics alone likely reduces power and also can lead to erroneous inferences. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：419 / 426

页数：8

共 22 条

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