Transcription regulation and animal diversity

被引：915
作者：
Levine, M
Tjian, R
机构：
[1] Univ Calif Berkeley, Ctr Integrat Genom, Dept Mol & Cell Biol, Div Genet & Dev, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
来源：
NATURE | 2003年 / 424卷 / 6945期
关键词：
D O I：
10.1038/nature01763
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.
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页码：147 / 151
页数：5
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