Spatiotemporal Dynamics of Immune Cells in Early Left Ventricular Remodeling After Acute Myocardial Infarction in Mice

被引:14
作者
Bejjani, Anthony T. [1 ]
Saab, Sally A. [1 ]
Muhieddine, Dina H. [2 ]
Habeichi, Nada J. [2 ]
Booz, George W. [3 ]
Zouein, Fouad A. [2 ]
机构
[1] Amer Univ Beirut, Med Ctr, Dept Biol, Fac Med, Beirut, Lebanon
[2] Amer Univ Beirut, Med Ctr, Dept Pharmacol & Toxicol, Fac Med, Beirut, Lebanon
[3] Univ Mississippi, Med Ctr, Sch Med, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA
关键词
cardiovascular diseases; cardiac inflammation; cardiac remodeling; myocardial infarction; GROWTH-FACTOR-BETA; CD4(+) T-LYMPHOCYTES; DENDRITIC CELLS; MAST-CELL; CARDIAC-FUNCTION; MACROPHAGE POLARIZATION; HEART FUNCTION; INFLAMMATORY RESPONSE; FIBROBLAST PHENOTYPE; THERAPEUTIC TARGET;
D O I
10.1097/FJC.0000000000000777
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial infarction remains a leading cause of morbidity and death. Insufficient delivery of oxygen to the myocardium sets into play a complicated process of repair that involves the temporal recruitment of different immune cells so as to remove debris and necrotic cells expeditiously and to form effective scar tissue. Clearly defined and overlapping phases have been identified in the process, which transitions from an overall proinflammatory to anti-inflammatory phenotype with time. Variations in the strength of the phases as well as in the co-ordination among them have profound consequences. Too strong of an inflammatory phase can result in left ventricular wall thinning and eventual rupture, whereas too strong of an anti-inflammatory phase can lead to cardiac stiffening, arrhythmias, or ventricular aneurisms. In both cases, heart failure is an intermediate consequence with death being the likely outcome. Here, we summarize the role of key immune cells in the repair process of the heart after left ventricular myocardial infarction, along with the associated cytokines and chemokines. A better understanding of the immune response ought to lead hopefully to improved therapies that exploit the natural repair process for mending the infarcted heart.
引用
收藏
页码:112 / 122
页数:11
相关论文
共 134 条
[21]   Interleukin-18 and IL-18 binding protein [J].
Dinarello, Charles A. ;
Novick, Daniela ;
Kim, Soohyun ;
Kaplanski, Gilles .
FRONTIERS IN IMMUNOLOGY, 2013, 4
[22]   Transforming growth factor (TGF)-β signaling in cardiac remodeling [J].
Dobaczewski, Marcin ;
Chen, Wei ;
Frangogiannis, Nikolaos G. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 51 (04) :600-606
[23]   Innate lymphoid cells: A new paradigm in immunology [J].
Eberl, Gerard ;
Colonna, Marco ;
Di Santo, James P. ;
McKenzie, Andrew N. J. .
SCIENCE, 2015, 348 (6237)
[24]   T-Helper 2 Immunity Is Associated With Reduced Risk of Myocardial Infarction and Stroke [J].
Engelbertsen, Daniel ;
Andersson, Linda ;
Ljungcrantz, Irena ;
Wigren, Maria ;
Hedblad, Bo ;
Nilsson, Jan ;
Bjorkbacka, Harry .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (03) :637-644
[25]   The varying faces of IL-6: From cardiac protection to cardiac failure [J].
Fontes, Jillian A. ;
Rose, Noel R. ;
Cihakova, Daniela .
CYTOKINE, 2015, 74 (01) :62-68
[26]   The interstitium in cardiac repair: role of the immune-stromal cell interplay [J].
Forte, Elvira ;
Furtado, Milena Bastos ;
Rosenthal, Nadia .
NATURE REVIEWS CARDIOLOGY, 2018, 15 (10) :601-616
[27]   The inflammatory response in myocardial infarction [J].
Frangogiannis, NG ;
Smith, CW ;
Entman, ML .
CARDIOVASCULAR RESEARCH, 2002, 53 (01) :31-47
[28]   IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury [J].
Frangogiannis, NG ;
Mendoza, LH ;
Lindsey, ML ;
Ballantyne, CM ;
Michael, LH ;
Smith, CW ;
Entman, ML .
JOURNAL OF IMMUNOLOGY, 2000, 165 (05) :2798-2808
[29]   The role of transforming growth factor (TGF)-β in the infarcted myocardium [J].
Frangogiannis, Nikolaos G. .
JOURNAL OF THORACIC DISEASE, 2017, 9 :S52-S63
[30]  
Frangogiannis Nikolaos G, 2015, Discoveries (Craiova), V3