Myocardial infarction remains a leading cause of morbidity and death. Insufficient delivery of oxygen to the myocardium sets into play a complicated process of repair that involves the temporal recruitment of different immune cells so as to remove debris and necrotic cells expeditiously and to form effective scar tissue. Clearly defined and overlapping phases have been identified in the process, which transitions from an overall proinflammatory to anti-inflammatory phenotype with time. Variations in the strength of the phases as well as in the co-ordination among them have profound consequences. Too strong of an inflammatory phase can result in left ventricular wall thinning and eventual rupture, whereas too strong of an anti-inflammatory phase can lead to cardiac stiffening, arrhythmias, or ventricular aneurisms. In both cases, heart failure is an intermediate consequence with death being the likely outcome. Here, we summarize the role of key immune cells in the repair process of the heart after left ventricular myocardial infarction, along with the associated cytokines and chemokines. A better understanding of the immune response ought to lead hopefully to improved therapies that exploit the natural repair process for mending the infarcted heart.
机构:
Univ Colorado Denver, Dept Med, Aurora, CO USA
Univ Med Ctr Nijmegen, Dept Med, Nijmegen, NetherlandsUniv Colorado Denver, Dept Med, Aurora, CO USA
Dinarello, Charles A.
;
Novick, Daniela
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机构:
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, IsraelUniv Colorado Denver, Dept Med, Aurora, CO USA
Novick, Daniela
;
Kim, Soohyun
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机构:
Konkuk Univ, Dept Biomed Sci & Technol, Seoul, South KoreaUniv Colorado Denver, Dept Med, Aurora, CO USA
Kim, Soohyun
;
Kaplanski, Gilles
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机构:
Aix Marseille Univ, UMR S 1076, Marseille, France
Hop Conception, AP HP, Serv Med Interne, Marseille, FranceUniv Colorado Denver, Dept Med, Aurora, CO USA
机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
Dobaczewski, Marcin
;
Chen, Wei
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机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
Chen, Wei
;
Frangogiannis, Nikolaos G.
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机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USAJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Forte, Elvira
;
Furtado, Milena Bastos
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机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USAJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Furtado, Milena Bastos
;
Rosenthal, Nadia
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h-index: 0
机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Imperial Coll London, Natl Heart & Lung Inst, Fac Med, Imperial Ctr Translat & Expt Med, London, EnglandJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
机构:
Albert Einstein Coll Med, Wilf Family Cardiovascu Res Inst, Dept Med Cardiol, Bronx, NY 10467 USAAlbert Einstein Coll Med, Wilf Family Cardiovascu Res Inst, Dept Med Cardiol, Bronx, NY 10467 USA
机构:
Univ Colorado Denver, Dept Med, Aurora, CO USA
Univ Med Ctr Nijmegen, Dept Med, Nijmegen, NetherlandsUniv Colorado Denver, Dept Med, Aurora, CO USA
Dinarello, Charles A.
;
Novick, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, IsraelUniv Colorado Denver, Dept Med, Aurora, CO USA
Novick, Daniela
;
Kim, Soohyun
论文数: 0引用数: 0
h-index: 0
机构:
Konkuk Univ, Dept Biomed Sci & Technol, Seoul, South KoreaUniv Colorado Denver, Dept Med, Aurora, CO USA
Kim, Soohyun
;
Kaplanski, Gilles
论文数: 0引用数: 0
h-index: 0
机构:
Aix Marseille Univ, UMR S 1076, Marseille, France
Hop Conception, AP HP, Serv Med Interne, Marseille, FranceUniv Colorado Denver, Dept Med, Aurora, CO USA
机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
Dobaczewski, Marcin
;
Chen, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
Chen, Wei
;
Frangogiannis, Nikolaos G.
论文数: 0引用数: 0
h-index: 0
机构:
Albert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USAAlbert Einstein Coll Med, Div Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10461 USA
机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USAJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Forte, Elvira
;
Furtado, Milena Bastos
论文数: 0引用数: 0
h-index: 0
机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USAJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Furtado, Milena Bastos
;
Rosenthal, Nadia
论文数: 0引用数: 0
h-index: 0
机构:
Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
Imperial Coll London, Natl Heart & Lung Inst, Fac Med, Imperial Ctr Translat & Expt Med, London, EnglandJackson Lab, 600 Main St, Bar Harbor, ME 04609 USA
机构:
Albert Einstein Coll Med, Wilf Family Cardiovascu Res Inst, Dept Med Cardiol, Bronx, NY 10467 USAAlbert Einstein Coll Med, Wilf Family Cardiovascu Res Inst, Dept Med Cardiol, Bronx, NY 10467 USA