MicroRNA signatures highlight new breast cancer subtypes

被引:33
作者
Bhattacharyya, Malay [1 ]
Nath, Joyshree [2 ]
Bandyopadhyay, Sanghamitra [2 ]
机构
[1] Indian Inst Engn Sci & Technol, Dept Informat Technol, Sibpur 711103, Howrah, India
[2] Indian Stat Inst, Machine Intelligence Unit, Kolkata 700108, India
关键词
Breast cancer; MicroRNA; Cancer subtype; Survival analysis; EXPRESSION; TUMORS; RISK;
D O I
10.1016/j.gene.2014.11.053
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:192 / 198
页数:7
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