The regulation of D2 dopamine receptor expression

被引：21
|
作者：
Hitzemann, RJ [1 ]
机构：
[1] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA
来源：
MOLECULAR PSYCHIATRY | 1998年 / 3卷 / 03期
关键词：
D O I：
10.1038/sj.mp.4000388
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The question of whether or not there is a polymorphism in or near DRD2 which is associated with receptor density remains unanswered. Both clinical and animal data demonstrate that D-2 dopamine receptor density is highly variable among individuals; differences of more than 100% are not uncommon. Among inbred mouse strains and F-2 intercrosses produced from these strains, it appears that most of the genetic variation in receptor expression is not associated with polymorphisms in or near Drd2.
引用
收藏
页码：198 / 203
页数：6
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