Kusnezosines A-C, three C19-diterpenoid alkaloids with a new skeleton from Aconitum kusnezoffii Reichb. var. gibbiferum

被引：16

作者：

Li, Yu-Zhu ^{[1
,2
]}

Qin, Li-Li ^{[1
]}

Gao, Feng ^{[1
]}

Shan, Lian-Hai ^{[1
]}

Zhou, Xian-Li ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Lab Chem & Biodivers, Chengdu 610031, Sichuan, Peoples R China

[2] Southwest Jiaotong Univ, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China

来源：

FITOTERAPIA | 2020年 / 144卷

关键词：

Ranunculaceae; Aconitum kusnezoffii Reichb. var. gibbiferum; Diterpenoid alkaloids; Kusnezosines A-C; Lactone D ring; Analgesic activity; ANTIOXIDANT;

D O I：

10.1016/j.fitote.2020.104609

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kusnezosines A-C (1-3), three C-19-diterpenoid alkaloids with a new skeleton which featured an undescribed lactone type D-ring, were isolated from the roots of Aconitum kusnezoffii Reichb. var. gibbiferum. Kusnezosines A-C are the first naturally occurred C-19-diterpenoid alkaloids which possessing an unprecedented lactone D ring, this structure was formed by the cleavage of bond between C-15 and C-16 and a successive lactonization. Their structures were established on the basis of comprehensive spectroscopic data analysis. Besides, another 12 known ones were isolated from this plant, analgesic activity tests on the isolated alkaloids were also carried out.

引用

页数：7

共 21 条

[1] Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum [J].