Ideal Cardiovascular Health in Childhood and Cardiometabolic Outcomes in Adulthood The Cardiovascular Risk in Young Finns Study

被引:220
作者
Laitinen, Tomi T. [1 ]
Pahkala, Katja [1 ,2 ]
Magnussen, Costan G. [1 ,5 ]
Viikari, Jorma S. A. [4 ]
Oikonen, Mervi [1 ]
Taittonen, Leena [6 ,7 ]
Mikkila, Vera [8 ]
Jokinen, Eero [9 ]
Hutri-Kahonen, Nina [12 ]
Laitinen, Tomi [10 ,11 ]
Kahonen, Mika [13 ]
Lehtimaki, Terho [14 ]
Raitakari, Olli T. [1 ,3 ]
Juonala, Markus [1 ,4 ]
机构
[1] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland
[2] Univ Turku, Paavo Nurmi Ctr, Sports & Exercise Med Unit, FIN-20520 Turku, Finland
[3] Univ Turku, Dept Clin Physiol, FIN-20520 Turku, Finland
[4] Univ Turku, Dept Med, FIN-20520 Turku, Finland
[5] Univ Tasmania, Menzies Res Inst, Hobart, Tas, Australia
[6] Vaasa Cent Hosp, Dept Pediat, Vaasa, Finland
[7] Univ Oulu, Dept Pediat, SF-90100 Oulu, Finland
[8] Univ Helsinki, Dept Appl Chem & Microbiol, Div Nutr, Helsinki, Finland
[9] Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland
[10] Kuopio Univ Hosp, Dept Clin Physiol, SF-70210 Kuopio, Finland
[11] Univ Eastern Finland, Kuopio, Finland
[12] Univ Tampere, Dept Pediat, FIN-33101 Tampere, Finland
[13] Univ Tampere, Dept Clin Physiol, FIN-33101 Tampere, Finland
[14] Univ Tampere, Dept Clin Chem, FIN-33101 Tampere, Finland
基金
芬兰科学院;
关键词
cardiovascular diseases; epidemiology; risk factors; children; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; DYSLIPIDEMIA CLASSIFICATIONS; ENDOTHELIAL FUNCTION; PHYSICAL-ACTIVITY; LIFETIME RISK; FOLLOW-UP; CHILDREN; ATHEROSCLEROSIS; ASSOCIATION;
D O I
10.1161/CIRCULATIONAHA.111.073585
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-The American Heart Association (AHA) defined a new concept, cardiovascular health, and determined metrics needed to monitor it over time as part of its 2020 Impact Goal definition. Ideal cardiovascular health is defined by the presence of both ideal health behaviors and ideal health factors. The applicability of this concept to a cohort of children and its relationship with cardiometabolic outcomes in adulthood has not been reported. Methods and Results-The sample comprised 856 participants aged 12 to 18 years (mean age 15.0 years) from the Cardiovascular Risk in Young Finns Study cohort. Participants were followed up for 21 years since baseline (1986) and had data available concerning health factors and behaviors in childhood and cardiometabolic outcomes in adulthood (2007). The number of ideal cardiovascular health metrics present in childhood was associated with reduced risk of hypertension (odds ratio [95% confidence interval] 0.66 [0.52-0.85], P<0.001), metabolic syndrome (0.66 [0.52-0.77], P<0.001), high low-density lipoprotein cholesterol (0.66 [0.52-0.85], P<0.001), and high-risk carotid artery intima-media thickness (0.75 [0.60-0.94], P<0.01) in adulthood. All analyses were age and sex adjusted, and the results were not altered after additional adjustment with socioeconomic status. Conclusions-The number of ideal cardiovascular health metrics present in childhood predicts subsequent cardiometabolic health in adulthood. Our findings suggest that pursuit of ideal cardiovascular health in childhood is important to prevent cardiometabolic outcomes in adulthood. (Circulation. 2012; 125: 1971-1978.)
引用
收藏
页码:1971 / 1978
页数:8
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