Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?

被引：4

作者：

Freville, Aline ^{[1
,2
]}

Gnangnon, Benedicte ^{[1
,3
]}

Khelifa, Asma S. ^{[1
]}

Gissot, Mathieu ^{[1
]}

Khalife, Jamal ^{[1
]}

Pierrot, Christine ^{[1
]}

机构：

[1] Univ Lille, CHU Lille, CNRS, INSERM,Inst Pasteur Lille,U1019 UMR 9017 CIIL Ctr, F-59000 Lille, France

[2] London Sch Trop Med & Hyg, Fac Infect & Trop Dis, Dept Infect Biol, Keppel St, London WC1E 7HT, England

[3] Harvard TH Chan Sch Publ Hlth, Ctr Communicable Dis Dynam, Dept Epidemiol, Boston, MA 02115 USA

来源：

MICROORGANISMS | 2022年 / 10卷 / 03期

关键词：

Apicomplexa; Plasmodium; Toxoplasma; protein phosphatases; phosphatome; serine; threonine phosphatases; tyrosine phosphatases; PP1; anti-malaria drug design; RICH REPEAT PROTEIN; PLASMODIUM-FALCIPARUM; MALARIA PARASITE; SERINE/THREONINE PHOSPHATASE; TYROSINE PHOSPHATASES; HOST-CELL; ANTIMALARIAL ACTIVITY; DEVELOPING-COUNTRIES; MAPK PHOSPHATASE; ACTIN DYNAMICS;

D O I：

10.3390/microorganisms10030585

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the scientific and medical communities with innovative strategies specifically targeting these organisms. In this review, we present an overview of the diversity of the phosphatome as well as the variety of functions that phosphatases display throughout the Apicomplexan parasites' life cycles. We also discuss how this diversity could be used for the design of innovative and specific new drugs/therapeutic strategies.

引用

页数：24

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