IRAK-4 inhibitors.: Part III:: A series of imidazo[1,2-a] pyridines

被引：51

作者：

Buckley, George M. ^{[1
]}

Fosbeary, Richard ^{[1
]}

Fraser, Joanne L. ^{[1
]}

Gowers, Lewis ^{[1
]}

Higueruelo, Alicia P. ^{[1
]}

James, Lynwen A. ^{[1
]}

Jenkins, Kerry ^{[1
]}

Mack, Stephen R. ^{[1
]}

Morgan, Trevor ^{[1
]}

Parry, David M. ^{[1
]}

Pitt, William R. ^{[1
]}

Rausch, Oliver ^{[1
]}

Richard, Marianna D. ^{[1
]}

Sabin, Verity ^{[1
]}

机构：

[1] UCB, Cambridge CB21 6GS, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 12期

关键词：

IRAK; IRAK-4; inhibitor; kinase; kinase inhibitor; imidazo[1,2-a] pyridine; inflammation; anti-inflammatory; ligand efficiency; IL-1; TNF-alpha; TNF alpha; immunity;

D O I：

10.1016/j.bmcl.2008.04.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a] pyridino-pyridines and benzimidazolo-pyridines was explored. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3656 / 3660

页数：5

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