IRAK-4 inhibitors.: Part III:: A series of imidazo[1,2-a] pyridines

被引：51

作者：

Buckley, George M. ^{[1
]}

Fosbeary, Richard ^{[1
]}

Fraser, Joanne L. ^{[1
]}

Gowers, Lewis ^{[1
]}

Higueruelo, Alicia P. ^{[1
]}

James, Lynwen A. ^{[1
]}

Jenkins, Kerry ^{[1
]}

Mack, Stephen R. ^{[1
]}

Morgan, Trevor ^{[1
]}

Parry, David M. ^{[1
]}

Pitt, William R. ^{[1
]}

Rausch, Oliver ^{[1
]}

Richard, Marianna D. ^{[1
]}

Sabin, Verity ^{[1
]}

机构：

[1] UCB, Cambridge CB21 6GS, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 12期

关键词：

IRAK; IRAK-4; inhibitor; kinase; kinase inhibitor; imidazo[1,2-a] pyridine; inflammation; anti-inflammatory; ligand efficiency; IL-1; TNF-alpha; TNF alpha; immunity;

D O I：

10.1016/j.bmcl.2008.04.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a] pyridino-pyridines and benzimidazolo-pyridines was explored. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3656 / 3660

页数：5

共 50 条

[21] Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline
Ducray, Richard
Jones, Clifford D.
Jung, Frederic H.
Simpson, Iain
Curwen, Jon
Pass, Martin
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (16) : 4702 - 4704
[22] Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b] pyridazine derivatives as potent PI3K/mTOR dual inhibitors
Li, Chuchu
Han, Yuqiao
Wang, Zhengyang
Yu, Yanan
Wang, Chen
Ren, Ziwei
Guo, Yanzhi
Zhu, Tong
Li, XuWen
Dong, Suzhen
Ma, Mingliang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 247
[23] 2-and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion
Sayer, James R.
Wallden, Karin
Pesnot, Thomas
Campbell, Frederick
Gane, Paul J.
Simone, Michela
Koss, Hans
Buelens, Floris
Boyle, Timothy P.
Selwood, David L.
Waksman, Gabriel
Tabor, Alethea B.
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (22) : 6459 - 6470
[24] Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors
Belema, Makonen
Bunker, Amy
Nguyen, Van N.
Beaulieu, Francis
Ouellet, Carl
Qu, Yuping
Zhang, Yunhui
Martel, Alain
Burke, James R.
Mclntyre, Kim W.
Pattoli, Mark A.
Daloisio, Connie
Gillooly, Kathleen M.
Clarke, Wendy J.
Brassil, Patrick J.
Zusi, F. Chris
Vyasa, Dolatrai M.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (15) : 4284 - 4289
[25] Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors
Hayakawa, Masahiko
Kaizawa, Hiroyuki
Kawaguchi, Ken-ichi
Ishikawa, Noriko
Koizumi, Tomonobu
Ohishi, Takahide
Yamano, Mayumi
Okada, Minoru
Ohta, Mitsuaki
Tsukamoto, Shin-ichi
Raynaud, Florence I.
Waterfield, Michael D.
Parker, Peter
Workman, Paul
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (01) : 403 - 412
[26] Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Jones, Eric D.
Vandegraaff, Nick
Le, Giang
Choi, Neil
Issa, William
Macfarlane, Katherine
Thienthong, Neeranat
Winfield, Lisa J.
Coates, Jonathan A. V.
Lu, Long
Li, Xinming
Feng, Xiao
Yu, Changjiang
Rhodes, David I.
Deadman, John J.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (19) : 5913 - 5917
[27] New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors
Moarbess, Georges
Guichou, Jean-Francois
Paniagua-Gayraud, Stephanie
Chouchou, Adrien
Marcadet, Olivier
Leroy, Fiona
Ruedas, Remi
Cuq, Pierre
Deleuze-Masquefa, Carine
Bonnet, Pierre-Antoine
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 115 : 268 - 274
[28] Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles
Spasov, A. A.
Zhukovskaya, O. N.
Brigadirova, A. A.
Abbas, H. S. A.
Anisimova, V. A.
Sysoeva, V. A.
Rashchenko, A. I.
Litvinov, R. A.
Mayka, O. Yu.
Babkov, D. A.
Morkovnik, A. S.
RUSSIAN CHEMICAL BULLETIN, 2017, 66 (10) : 1905 - 1912
[29] 4-(Imidazo[1,2-a]pyridin-3-yl): pyrimidine derivatives as anticancer agents
Al-Horani, Rami A.
PHARMACEUTICAL PATENT ANALYST, 2023, 12 (01) : 13 - 18
[30] SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase
Hieke, Martina
Roedl, Carmen B.
Wisniewska, Joanna M.
la Buscato, Estel
Stark, Holger
Schubert-Zsilavecz, Manfred
Steinhilber, Dieter
Hofmann, Bettina
Proschak, Ewgenij
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (05) : 1969 - 1975

← 1 2 3 4 5 →